Pfizer Corporation

Bristol-myers Squibb Compnay

Grant Wickman

Haichun Huang

Brigitte Devaux

Peter Brams

Steven Lee Bender

Haibin Chen

Kristopher Toy

Mark Yamanaka

Dawn M Tanamachi

Lan Yang

Michael Aidan North

Gerald Fries Casperson

Gang Li

Xin Jiang

Dana Dan Hu-Lowe

Tim Sproul

Jianying Wang

Tim W Sproul

The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, or antigen binding portions thereof, that specifically bind to integrin &#x3b1;5&#x3b2;1 with high affinity. Nucleic acid molecules encoding the antibodies of the disclosure, expression vectors, host cells and methods for expressing the antibodies of the disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies or antigen binding portions thereof are also provided. The disclosure also provides methods for treating various cancers using the anti-&#x3b1;5&#x3b2;1 antibodies or antigen binding portions thereof described herein.

Alpha5-beta1 antibodies and their uses

Alpha 5-beta 1 antibodies and their uses

Growing community of inventors

Glasgow, United Kingdom

Grant Wickman