Amgen Inc.

Other

Grant Shimamoto

Kenneth William Walker

Gunasekaran Kannan

Agnes Eva Hamburger

Jackie Zeqi Sheng

Zhulun Wang

Yi Lin Zhang

Xiaoshan Min

Murielle M Veniant-Ellison

YuMei Xiong

Jie Tang

Bryan D Lemon

Li Zhang

Mei-Mei Tsai

Kevin Graham

Xueming Qian

Aaron George Winters

Yi Zhang

Marissa Mock

Barbara S Tipton

Yumei Xiong

GDF15 polypeptides, constructs comprising GDF15, and mutants thereof are provided. In various embodiments the GDF15 polypeptides, constructs comprising GDF15, and mutants thereof, can be of use in the treatment or ameliorating a metabolic disorder. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy.

Growth differentiation factor 15 (GDF-15) polypeptides

Constructs comprising GDF15, and mutants thereof are provided. In various embodiments the constructs comprising GDF15, and mutants thereof, can be of use in the treatment or ameliorating a metabolic disorder. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy.

Growth differentiation factor 15 (GDF-15) constructs

The present invention relates to binding agents for WISE, and includes for their manufacture and use.

Wise binding agents and epitopes

Growing community of inventors

Westlake Village, CA, United States of America

Grant Shimamoto