Combinatorx, Incorporated

Zalicus, Inc.

Grant R Zimmermann

Curtis Keith

Alexis Borisy

Palaniyandi Manivasakam

Edward Roydon Jost-Price

Nicole Hurst

Robyn Sackeyfio

Jason Fong

Michael Andrew Foley

Margaret S Lee

M James Nichols

Michael S Slavonic

Brendan Smith

Benjamin A Auspitz

Alyce L Finelli

Daniel Grau

Michael A Foley

The invention features a method for treating a patient diagnosed with, or at risk of developing, an immunoinflammatory disorder by administering to the patient a tetra-substituted pyrimidopyrimidine, either alone or in combination with one or more additional agents. The invention also features a composition containing a tetra-substituted pyrimidopyrimidine in combination with one or more additional agents.

Methods and reagents for the treatment of immunoinflammatory disorders

The invention features pharmaceutical compositions that include dipyridamole and a corticosteroid.

Combinations for the treatment of immunoinflammatory disorders

The invention features compositions, methods, and kits for the treatment of metabolic disorders such as diabetes and obesity.

Methods and reagents for the treatment of metabolic disorders

The invention features methods and compositions for the treatment of immunonflammatory disorders.

Combinations for the treatment of inflammatory disorders

The invention features a pharmaceutical composition that includes amoxapine and a corticosteroid.

The invention features a method for treating a patient having an inflammatory disorder, by administering to the patient (i) a tricyclic antidepressant (e.g., amoxapine); and (ii) a corticosteroid (e.g., prednisolone) simultaneously or within 14 days of each other in amounts sufficient to reduce or inhibit inflammation.

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Somerville, MA, United States of America

Grant R Zimmermann