Children's Medical Research Institute

The Sydney Children's Hospitals Network (randwick and Westmead) (incorporating the Royal Alexandra Hospital for Children)

Haemalogix Pty. Ltd.

Haemalogix Ltd

Grant Logan

Ian Alexander

Allison Dane

Kenneth Micklethwaite

Rosanne Dunn

David Gottlieb

The present invention provides compositions and methods for treating KMA-expressing malignancies including chimeric antigen receptors (CARs) and T cells containing CARs (CAR T-cells). The invention also provides methods and compositions comprising CAR T-cells co-expressing other anti-tumoral agents including cytokines and antibodies.

Kappa myeloma antigen chimeric antigen receptors and uses thereof

The present disclosure relates generally to promoters derived from the AAV anti-sense strand, their use in the expression of one or more heterologous coding sequences, and isolated polynucleotides, vectors and recombinant viruses comprising the promoters. The present disclosure also relates to enhancers derived from the AAV anti-sense strand, their use in increasing the expression of one or more heterologous coding sequences, and isolated polynucleotides, vectors and recombinant viruses comprising the enhancers.

Promoters for expression of heterologous genes

Growing community of inventors

Westmead, Australia

Grant Logan