Deutsches Krebsforschungszentrum

Ruprecht-Karls-Universitat Heidelberg

Universitat Heidelberg

Griffith University

Grant Hansman

Anna Koromyslova

The present invention relates to a binding polypeptide specifically binding to an epitope comprised in an amino acid sequence corresponding to amino acids 250 to 300 of the norovirus genotype II.10 capsid polypeptide, and to a polynucleotide encoding the same. The present invention further relates to a composition comprising the binding polypeptide according to the present invention and a carrier, and to the binding polypeptide or the composition comprising the same use in diagnosis and/or for use in medicine. Further more, the present invention relates to kits, devices, vaccines, methods, and uses related to the binding polypeptide of the present invention.

Norovirus antibodies

The present invention relates to a binding polypeptide specifically binding to the amino acid sequence W-V-N-X-F-Y-X(SEQ ID NO: 1), wherein Xrepresents any amino acid, preferably Q or P, and wherein Xrepresents any amino acid, preferably, T or S in a norovirus polypeptide. The present invention further relates to polynucleotide encoding a binding polypeptide of the present invention an to a host cell comprising the same or the polynucleotide of the invention. The present invention further relates to a method of detecting the presence of a norovirus capsid polypeptide in a sample and to kits, devices, and uses making use of the binding peptide of the invention.

Growing community of inventors

Heidelberg, Germany

Grant Hansman