Smithkline Beecham Corporation

Smith Kline & French Laboratories Limited

Laboratories Smith Kline & French

Graham S Leonard

David Elder

Gordon France

Geoffrey D Tovey

Kevin E Pearmain

Rene Tarral

John N Healey

Jacky Mention

Brian A Carlin

David Cooper

A controlled release or delayed release formulation contains a selective serotonin reuptake inhibitor (SSRI) such as paroxtine.

Paroxetine controlled release compositions

A controlled release or delayed release formulation contains a selective serotonin reuptake inhibitor (SSRI) such as paroxetine.

Controlled release compositions

Pharmaceutical tablet

Oral liquid compositions containing paroxetine resinate

Spray-chilled nabumetone

Chewable tablets containing unpleasant tasting medicaments such as cimetidine are provided. The palatability of the tablets is improved by including certain hygroscopic water-insoluble substances as extragranular excipients in amounts corresponding to 5% (w/w) to 15% (w/w) of the table.

Pharmaceutical compositions

Delayed-release oral dosage forms are described comprising cimetidine or a salt thereof and optionally a buffer that is capable of aiding dissolution of cimetidine in the intestine, coated with a release-delaying substance comprising a coating agent such as Eudragit.RTM. L 30 D.

The invention provides pharmaceutical suspension compositions of cimetidine wherein substantially all of the cimetidine is in the polymorph B crystalline form.

Pharmaceutical formulations

Growing community of inventors

St. Albans, United Kingdom

Graham S Leonard