Knoll Gmbh

Knoll Pharmaceutical Company

Graham Paul Luscombe

Patricia Lesley Needham

David John Heal

Sharon C Cheetham

Substituted cycloalkyl compounds with 3 to 6 carbon atoms in the ring, one carbon linked to each of two side groups R and R', and pharmaceutically acceptable salts thereof in which R is phenyl optionally substituted by one or more halo substituents or R is naphthyl; and R&#x2032; is &#x2014;[X&#x2014;Y&#x2014;S(O)-Z-N&#x2014;R&#x2014;R], wherein X is carbonyl or a carbon directly linked to each of a hydroxyl group and Rin which Ris H or alkyl, Y is an alkylene chain optionally substituted by one or more alkyl groups, m can be 0, 1 or 2, Z is an alkylene chain containing 2 to 5 carbon atoms optionally substituted by one or more alkyl groups, and Rand R, which are the same or different, are H, alkyl, or arylalkyl, provided that when Ris benzyl, Ris H or methyl; have utility in the treatment of drug misuse or other addictive disorders.

Therapeutic Agents

Compounds of formula (I) and pharmaceutically acceptable salts thereof in which m is 0, 1 or 2; n is 2, 3, 4 or 5; X is carbonyl or a group of formula (II) in which Ris H or alkyl; Y is an alkylene chain optionally substituted by one or more alkyl groups; Z is an alkylene chain containing 2 to 5 carbon atoms optionally substituted by one or more alkyl groups; R is phenyl optionally substituted by one or more halo substituents or R is naphthyl; and Rand R, which are the same or different, are H, alkyl, or arylalkyl, provided that when Ris benzyl, Ris H or methyl; have utility in the treatment of drug misuse or other addictive disorders.

Growing community of inventors

Nottingham, United Kingdom

Graham Paul Luscombe