Bioeos Limited

Ucl Biomedica Plc

University College London

Ucl Business Plc

Graham McIntyre

John Lawson Stanford

Oscar Adelmo Bottasso

Cynthia Ann Stanford

The present invention relates to a method of producing rough strains of a bacterium, such as, said method comprising exposing said bacterium to a sulfone and/or sulfonamide (such as 4,4'-Diaminodiphenyl sulfone or an analogue thereof). A rough strain ofproducible by said method and uses thereof. In particular, uses of a rough strain ofdeposited under the Budapest Treaty at the NCTC with the accession number NCTC 13365.

Method of producing rough strains of bacteria and uses thereof

Use of whole cells of bacteria from the genera of aerobic organisms in the order of Actinomycetales in the manufacture of a medicament for the treatment or prevention of Type II diabetes and/or obesity and methods of treating or preventing Type II diabetes and/or obesity in a subject by administering an effective amount of a composition comprising a whole cell of a bacterium from a genera of aerobic organisms in the order of Actinomycetales to said subject. Preferably the bacteria is from one or more of the following genera for example:and

Method of treating and/or preventing type II diabetes using Actinomycetales

An immune modulator composition and/or pharmaceutical composition comprising a whole cell of a bacterium from the generaand, wherein said immune modulator composition in use modifies a cellular immune response.

Whole bacterial cells as immune modulator

This invention relates to a method for treating or preventing (including immunising against) post-wearing multisystemic wasting syndrome (PMWS) and/or porcine dermatitis and nephropathy syndrome (PDNS) in a subject comprising administering an effective amount of a pharmaceutical composition or immune modulator composition comprising a whole cell of a bacterium from one or more of the generaand, to said subject. In addition the method relates to the use of an immune modulator composition or a pharmaceutical composition comprising a whole cell of a bacterium from the generaand, in the manufacture of a medicament for the treatment or prevention of post-wearing multisystemic wasting syndrome (PMWS) and/or porcine dermatitis and nephropathy syndrome (PDNS).

Composition for increasing the survival to slaughter rate of piglets

Use of an immune modulator composition and/or pharmaceutical composition comprising a whole cell of a bacterium from the generaand, for use in the manufacture of a medicament for the treatment of an autoimmune disease or autoimmune disorder, including certain vascular disorders.

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West Wickham, United Kingdom

Graham McIntyre