Warner-lambert Company

Hoechst (uk) Limited

Other

Hoechst Aktiengesellschaft

Research Institute for Medicine & Chemistry, Inc.

Graham Johnson

Michael Francis Rafferty

Christopher Franklin Bigge

Barry C Ross

Michael R Pavia

Charles Price Taylor, Jr

Devin Franklin Welty

Thomas C Malone

Michael A Yeomans

Po-wai Yuen

Perry M Novak

Robert H Hesse

Daniel Fred Ortwine

Sheryl Jeanne Hays

Linda L Coughenour

Vlad E Gregor

James T Drummond

A hay bale lifting and transport device is mounted on a transport vehicle having a cab and having a rear bed area located behind the cab which defines a generally rectangular shaped, exposed top planar surface. The lifting apparatus includes a pair of elongate hay bale spikes affixed to a mounting assembly so that the spikes are spaced apart a fixed distance and are arranged in a plane parallel to one another. The spikes and mounting assembly are received in an opening formed in the rear planar bed of the transport vehicle when the spikes are in a first, fully retracted position, the central axis of each of the spikes being located below the plane of the rear bed. An actuating mechanism acts upon the mounting assembly for moving the pair of spikes around a pivot axis between the fully retracted position and an extended position in which the spikes are arranged to engage a bale of hay.

Hay bale lifting and transport apparatus

The present invention relates to a pharmaceutical composition containing a kainate excitatory amino acid antagonist and an uricosuric agent and to a method of treating neurodegenerative diseases using a combination of a kainate excitatory amino acid antagonist and an uricosuric agent.

Pharmaceutical composition and a method for treating neurodegenerative

The present invention is a pharmaceutical composition having a combination of an uricosuric agent such as probenecid or the like and an excitatory amino acid antagonist useful for treating a disease advantageously affected by treatment with an excitatory amino acid antagonist.

Method of treating neurodegenerative diseases using an AMPA excitatory

Pharmaceutical composition for and a method of using a combination of an

The present invention relates to novel 3-substituted-2-carboxyindoles; including as 3-substituents amides of hydroxamic acids and derivatives thereof or urea and carbonyl, carboxyl or phosphonic acids or ester amides, or 2-acylsulfonamides thereof; and including also as 3-substituents unsaturated acids and their further ester and amide derivatives. These 2-carboxyindoles are useful as pharmaceutical agents, therefore, the present invention is also pharmaceutical compositions and pharmaceutical methods of treatment therefor. The compounds of the present invention are useful in the treatment of neurodegenerative disorders including cerebrovascular disorders.

Derivatives of 2-carboxyindoles having pharmaceutical activity

A novel series of polycyclic amines, derivatives, methods of making the compounds, novel intermediates, compositions containing them, and methods for using them in the treatment and prevention of cerebrovascular disorders are disclosed.

Polycyclic amines useful as cerebrovascular agents

The present invention is novel substituted .alpha.-amino acids, pharmaceutical compositions, methods of use, and preparations therefore having utility for treating disorders which benefit from blockade of aspartate and glutamate receptors.

Substituted .alpha.-amino acids having selected acidic moieties for use

The present invention is novel compounds, which are derivatives of 4'-hydroxyphenylacetic acid having antiinflammatory activity for the treatment of arthritis, asthma, Raynaud's disease, inflammatory bowel disorders, trigeminal or herpetic neuralgia, inflammatory eye disorders, psoriasis, and having analgesic activity. Particularly, the analgesia may be useful for the treatment of dental pain and headache, especially vascular headache, such as migraine, cluster and mixed vascular syndromes, as well as nonvascular tension headache.

Substituted 4'-hydroxyphenylacetic acid derivatives having

A method of treatment of central nervous system disorders with compounds having the formula ##STR1## and isomers thereof wherein R.sup.1, R.sup.2, R.sup.4, R.sup.5, R.sup.6, and R.sup.7 and as defined in the specification; as well as pharmaceutical compositions thereof.

Isatine derivatives, and their method of use

N-substituted .alpha.-amino acids and derivatives thereof are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful in selectively blocking the N-methyl-D-aspartate (NMDA) excitatory amino acid receptors in mammals and also are useful in treating cerebrovascular disorders such as cerebral ischemia or cerebral infarction resulting from thromboembolic or hemorrhagic stroke, cerebral vasospasm, hypoglycemia, cardiac arrest, status epilepticus and cerebral trauma as well as for treating schizophrenia, epilepsy, neurodegenerative disorders, Alzheimer's disease or Huntington's disease and also additionally useful as anesthetics in surgical procedures where a finite risk of cerebrovascular damage exists.

N-substituted .alpha.-amino acids and derivatives thereof having

The present invention is novel substituted .alpha.-amino acids, pharmaceutical compositions, method of use, and preparations therefore having utility for treating disorders which benefit from blockade of aspartate and glutamate receptors.

Substituted alpha-amino acids having pharmaceutical activity

The present invention relates to novel compounds, which are derivatives of ureas, thioureas, carbamates, sulfonylureas, sulfonamides, amides, and thioamides of 2-carboxyindoles as illustrated by the formula ##STR1## The invention also relates to methods for the preparation of the novel compounds, as well as to pharmaceutical compositions or methods of use for the novel compounds. More specifically, the compounds of the present invention are useful in the treatment of neurodegenerative disorders including cerebrovascular disorders as well as in the treatment of schizophrenia or epilepsy; and as analgesics and anxiolytics.

Substituted 2-carboxylindoles having pharmaceutical activity

The present invention relates to novel tetracyclic amines and derivatives thereof useful as pharmaceutical agents, to methods for their production, to pharmaceutical compositions which include these compounds and a pharmaceutically acceptable carrier, and to pharmaceutical methods of treatment. The compounds of the present invention are useful in the treatment of neurodegenerative disorders including cerebrovascular disorders.

Growing community of inventors

Ann Arbor, MI, United States of America

Graham Johnson