Case Western Reserve University

Neurostim Solutions LLC

Neurostim Oab, Inc.

Graham Harold Creasey

Hoo-min D Toong

Warren M Grill

Kenneth J Gustafson

Alan Eton Loh

Michael Bernard Druke

Anthony Wei

Robert W Scott

J Thomas Mortimer

Hoo-Min Toong

Hoo-Min D Toong

Warren M Grill, Jr

Zi-Ping Fang

David A Ksienski

Claude S Veraart

A topical nerve stimulator patch and system are provided including a dermal patch; an electrical signal generator associated with the patch; a signal receiver to activate the electrical signal generator; a power source for the electrical signal generator associated with the patch; an electrical signal activation device; and a nerve feedback sensor.

Non-invasive nerve stimulation

One example provides a nerve stimulation treatment using electrodes coupled to a user. Examples determine a target charge level and output a series of pulses from the electrodes. For each pulse outputted, examples measure a charge value of the pulse and compare the charge value to the target charge level. If the charge value is greater than the target charge level, examples reduce a strength level of a subsequent outputted pulse. If the charge value is less than the target charge level, examples increase the strength level of a subsequent outputted pulse.

Topical neurological stimulation

What is provided is a method and apparatus for modifying bladder function comprising: applying a dermal patch having an integral electrode in proximity to a sacral or pudendal nerve; selecting the sacral or pudendal nerve by a sensor integral on the dermal patch; determining a stimulation corresponding to the sacral or pudendal nerve, by logic of the dermal patch; applying the stimulation by the electrodes and a stimulator integral to the dermal patch to produce an electric field; and selectively activating the sacral or pudendal nerve by the electric field.

Topical nerve stimulator and sensor for bladder control

A topical nerve activation patch includes a flexible substrate, a dermis conforming bottom surface of the substrate comprising adhesive and adapted to contact a dermis of a user, a flexible top outer surface of the substrate approximately parallel to the bottom surface, a plurality of electrodes positioned on the patch proximal to the bottom surface and located beneath the top outer surface and coupled to the flexible substrate, a power source, and electronic circuitry that generates an output voltage applied to the electrodes. The electronic circuitry includes a controller, a voltage monitoring circuit coupled to the controller, a current monitoring circuit coupled to the controller, a switch coupled to the controller and a boosted voltage circuit coupled to the switch and the power source.

Non-invasive nerve activator with adaptive circuit

A topical nerve stimulator patch and system are provided comprising a dermal patch; an electrical signal generator associated with the patch; a signal receiver to activate the electrical signal generator; a power source for the electrical signal generator associated with the patch and an electrical signal activation device.

A topical nerve stimulator patch and system are provided comprising a dermal patch; an electrical signal generator associated with the patch; a signal receiver to activate the electrical signal generator; a power source for the electrical signal generator associated with the patch; an electrical signal activation device; and a nerve feedback sensor.

Systems and methods selectively stimulate components of the pudendal nerve away from the sacral root to evoke desired physiologic responses in persons who lack the ability to otherwise produce these responses&#x2014;e.g., maintain continence and/or produce micturition, and/or provide male/female sexuality responses, and/or provide bowel responses. The systems and methods use a multiple electrode array, or individual electrodes, placed on, in, or near the pudendal nerve. The electrode array, or individual electrodes, in association with a pulse generator, provide selective stimulation of individual fascicles within the pudendal nerve, to achieve different physiologic responses.

Systems and methods for selectively stimulating components in, on, or near the pudendal nerve or its branches to achieve selectively physiological responses

Systems and methods for selectively stimulating components in, on, or near the pudendal nerve or its branches to achieve selective physiologic responses

Methods for selectively stimulating components in, on, or near the pudendal nerve or its branches to achieve selective physiologic responses

A sheet (30) of polymeric material defines a cuff portion (A), a contact portion (B), and an interconnecting elongated lead portion (C). Using physical vapor deposition (PVD), chemical vapor deposition (CVD), or other thin film deposition techniques, a plurality of electrodes (12), contact pads (16), and interconnecting leads (14) are deposited on the base layer. An elastomer covering layer (18) is laminated to the base layer. The elastomeric covering layer is stretched along direction (24) before lamination, such that at least the cuff portion is elastomerically biased to curl into a spiral. Windows (20) are defined in the elastomeric portion to provide for electrical conduction between the electrodes (12) and nerve tissue about which the cuff electrode is wrapped. The electrodes are arced (FIG. 6) such that they are more recessed adjacent sides of the window than adjacent the center in order to provide a substantially uniform flux density across the electrode surface.

Thin film implantable electrode and method of manufacture

Cuff electrodes (40a, 40b) are surgically implanted around S.sub.3 sacral ventral root nerve trunks (16a, 16b). The sacral ventral roots have smaller diameter nerve fibers (20a, 20b) which convey action potentials to cause detrusor activation to contract the bladder (10) and larger diameter nerve fibers (18a, 18 b) which carry action potentials for causing contraction of a urethral sphincter (12) to block the flow of urine from the bladder. A current source (50) causes current pulses (52) between such electrical contacts (46, 48) and a central electrical contact (44). The current pulses have an appropriate amplitude and waveform to initiate action potentials adjacent the central contact and to block the propagation of action potentials adjacent the end electrodes along the larger diameter nerve fibers (which have fewer nodes between the contacts) but not the smaller diameter nerve fibers (which have more nodes between the electrodes). In this manner, action potentials are electrically excited to propagate at least downstream on the smaller diameter nerve fibers causing contraction of the bladder. Concurrently, blocking action potentials are allowed to propagate upstream on at least the larger diameter nerve fibers, collision blocking naturally occurring action potentials propagating downstream. The transmission of action potentials downstream on the larger diameter nerve fibers is blocked by the current pulses allowing the urinary sphincter to relax.

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Menlo Park, CA, United States of America

Graham Harold Creasey