Smithkline Beecham Corporation

Genentech, Inc.

Glaxo Group Limited

F. Hoffmann-la Roche Ag

Graham Elgin Jones

David Thomas Davies

Neil David Pearson

Ian Thomson Forbes

Timothy Heffron

Andrew Madin

Bryan K Chan

Jun Liang

Eileen Mary Seward

Lewis J Gazzard

Roger Edward Markwell

Michael Siu

Sushant Malhotra

Emanuela Gancia

Michael Lainchbury

Craig Stivala

Kin Chiu Fong

Rohan V Mendonca

Yonghan Hu

Matthew W Cartwright

John Tellis

David Favor

Andrew Good

William Henry Miller

Laramie Mary Gaster

Paul Adrian Wyman

BinQing Wei

Keith Raymond Mulholland

David Malcolm Duckworth

Naomi S Rajapaksa

Joy Drobnick

Israil Pendrak

Timothy James Miles

Robert A Daines

Timothy Francis Gallagher

Alan G Olivero

Robert Andrew Heald

Chudi Obioma Ndubaku

Alan Joseph Hennessy

Weiru Wang

Jeffrey Michael Axten

Lan Wang

Aihe Zhou

Binqing Wei

Andrew Lightfoot

Jennafer Dotson

Aijun Lu

Malcolm Huestis

Baihua Hu

Blake Daniels

Gerald Brooks

Peter Ham

Neville James McLean

Sussie Lerche Krintel

Laurent Salphati

Francis D King

Steven Dabbs

Terry Kellar

Ilaria Giordano

Roger T Martin

Julia Castro Pichel

Jose Maria Fiandor Roman

Angela Moghe

BinQuing Wei

Lluis Ballell

David Barros

Modesto J Remuiñan Blanco

Jason Anthony Rossi

James B Hoffman

Lihua(lily) Zhang

Nathalie Cailleau

Lihua Zhang

Neville James Mclean

Chudi Ndubaku

Naomi Rajapaksa

John C Tellis

Modesto J Remuinan Blanco

Isoquinoline compounds of formula (I): variations thereof, and their use as inhibitors of HPK1 (hematopoietic kinase 1) are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the isoquinoline compounds.

Isoquinoline compounds and uses thereof

Naphthyridine compounds and uses thereof

Naphthyridine compounds and their use as inhibitors of HPK1 are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the naphthyridine compounds.

Naphthyridines as inhibitors of HPK1

Tricyclic PI3k inhibitor compounds of Formula I with anti-cancer activity, anti-inflammatory activity, or immunoregulatory properties, and more specifically with PI3 kinase modulating or inhibitory activity are described. Methods are described for using the tricyclic PI3K inhibitor compounds of Formula I for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, organisms, or associated pathological conditions.  Formula I compounds include stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof. The dashed lines indicate an optional double bond, and at least one dashed line is a double bond. The substituents are as described.

Tricyclic PI3K inhibitor compounds and methods of use

Bicyclic nitrogen containing compounds and their use as antibacterials.

Derivatives and analogs of N-ethylquinolones and N-ethylazaquinolones

Tricyclic nitrogen containing compounds of formula (I) and their use as antibacterials.

Heterocyclic compounds, their preparation and their use as antibacterials

Tricyclic nitrogen containing compounds and their use as antibacterials.

Pyrrolo-quinoxalinone derivatives as antibacterials

Cyclohexane and cyclohexene derivatives and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly man.

Antibacterial compounds

Aminopiperidine derivatives and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly in man 

Aminopiperidine quinolines and their azaisosteric analogues with antibacterial activity

Piperidine derivatives and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly in man. The piperidine derivatives include compounds of formula (I): wherein R, AB, n, R, Rand Rare defined herein. For example, Ris an optionally substituted bicyclic carbocyclic or heterocyclic ring system, and Ris a group U-Rin which Ris an optionally substituted bicyclic heterocyclic ring system as defined herein (e.g. optionally substituted pyrido [3,2, -b][1,4] thiazin-yl).

Compounds

Piperidine derivatives and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly in man. 

Quinolines and nitrogenated derivative thereof substituted in 4-position by a piperidine-containing moiety and their use as antibacterial agents

Nitrogen-containing bicyclic heterocycles for use as antibacterials

Aminopiperidine derivatives and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly in man.

Aminopiperidine quinolines and their azaisosteric analogues with antibacterical activity

Growing community of inventors

Hertford, United Kingdom

Graham Elgin Jones