University College London

Monsanto Company

Stanford Rook Limited

Other

Portalab Instruments Limited

Graham A Rook

John Lawson Stanford

Raymond A Dwek

Thomas William Rademacher

Christopher W Redman

Peter D Arkwright

John L Stanford

Irun R Cohen

Hugo Norberto Caro

Willem Van Eden

John Spencer Emtage

Thomas W Rademacher

Alimuddin L Zumla

Joseph Holoshitz

Ayala Frenkel

Roland Foulkes

Mark William Bodmer

Laura Rosa Brunet

Martin Rae Wales

Colin H Cameron

The invention relates to a compound which is an ester of 1,2,3-propanetriol with one or more Cto Cfatty acids, wherein at least one fatty acid has at least one double bond. The compound is useful in the treatment of chronic inflammatory disorders.

Immunotherapeutic agent

Antigenic and/or immunogenic material derived fromis used to down-regulate Th2 activity of the immune system without up-regulation of Th1 activity. Disorders such as Chronic Fatigue Syndrome, Gulf War Syndrome and Total Allergy Syndrome are treated. The material preferably comprises deadcells in a composition which does not include a non-antigen, immunogen or allergen.

Mycobacterium vaccae for down-regulation of the Th2 activity of the immune system

Hormone and growth factor phosphoglycokine mimetics from mycobacterium

Immunotherapeutic agent and its use

Use of estrone derivatives as steroid sulphatase inhibitors

Mycobacterium vaccae for treatment of long term autoimmune conditions

Immunoregulatory material derived from Mycobacterium vaccae, especially dead cells of M. vaccae, are useful for the treatment of pathological conditions (other than mycobacterial disease and arthritic disease) in a patient in which the patient's IgG shows an abnormally high proportion of agalactosyl IgG and for the treatment of chronic inflammatory disorders (other than an arthritic disease) caused or accompanied by an abnormally high release from macrophages of interleukin-6 and/or tumor necrosis factor.

Treatment of psoriasis using dead cells of Mycobacterium vaccae

Immunoregulatry material from a mycobacterium other an M. tuberculosis, especially killed cells of M. vaccae, is an advantageous adjuvant for administration with antigens (including allergens).

Mycobacterium as adjuvant for antigens

The disclosure describes novel immunosuppressive agents isolated from syncytiotrophoblast microvilli membranes by preparing a minutely subdivided and solubilized preparation of said membranes and isolating the unreduced N-linked oligosaccharides from an extract of said preparation.

Immunosuppressive agents

Method for producing immunosuppressive agents

The disclosure describes novel immunosuppressive agents isolated from syncytiotrophoblast microvilli membranes by preparing a minutely subdivided and solubilized preparation of said membranes and isolating the unreduced N-linked oligosaccharides from an extract of the preparation.

Immunosuppressive glycoprotein

Immuno-therapeutic composition of killed cells from mycobacterium vaccae

Methods for the alleviation or treatment of arthritic disease

A portable photometer for measuring the transmission properties of a fluid contained in a container having a transparent bottom is disclosed which is characterized in that there is provided: a monochromatic light source and a collimator assembly, both of which are contained within the base of a moveable member; a locating member arranged to contact the top of the container to thereby locate the end of the tubular member at a predetermined position with respect to the bottom of the container; and a photodetector device positioned beneath the container to receive the light from the collimator.

Portable photometer

Growing community of inventors

London, United Kingdom

Graham A Rook