The Secretary of State for Defence in Her Brittanic Majesty's Government of the United Kingdom of Great Britain and Northern Ireland

The Secretary of State for Defence

Graeme Peter Nicholson

Mark Joseph Kan

Paul D Beer

Michael G Drew

Gareth Williams

Caroline Jane Evans-Thompson

Arfon Harris Jones

Christopher William Hall

A calixarene dimer of the general formula (I-G), comprising a first calixarene moiety I and a second calixarene moiety G, wherein: L is [&#x2014;CH&#x2014;] or [&#x2014;O&#x2014;CH&#x2014;O&#x2014;] and is the same or different between each aryl group; Ris H, NO, halogen, or C-Caliphatic hydrocarbyl group, C-Caryl group, C-Chydrocarbylaryl group, any of which is optionally substituted by one or more halo or oxo groups or interrupted by one or more oxo or amide groups, and Ris the same or different on each aryl group; Rcomprises a carboxy group which is or is not protonated or protected; two groups out of R, Rand Rare H; the one group out of R, Rand Rnot being H comprises at least one atom of one or more of O and S, the said at least one atom being capable of causing the calixarene to be adsorbed onto the surface of the substrate; and the one group out of R, Rand Rnot being H being conjugated to the second calixarene moiety G. The calixarene dimers may be incorporated into sensors. Methods of making the calixarene dimers are disclosed.

Calixarenes and calixarence-based sensors

Disclosed are &ldquo;acid-amide&rdquo; calixarenes of formula (I) wherein: L is &lsqb;&mdash;CH &mdash;&rsqb; or &lsqb;&mdash;O&mdash;CH &mdash;O&mdash;&rsqb; and may be the same or different between each aryl group R is H, halogen, or C aliphatic hydrocarbyl group, C aryl group, any of which may optionally be substituted by one or more halo or oxo groups or interrupted by one or more oxo groups, and R may be the same or different on each aryl group; R comprises an optionally protected carboxy group; two groups out of R , R , and R , are H; the one group out of R , R , and R not being H comprises an amide group. The amide group may be linked to a second calixarene to form a dimer. Also disclosed are methods of use of such calixarenes for the purposes of metal sequestration, especially of lanthanides and actinides. Also disclosed are calixarene dimer derivatives of the calixarenes of the invention. Also disclosed are processes for preparing the calixarenes and dimers

Calixarenes and their use for sequestration of metals

Disclosed are &ldquo;acid-amide&rdquo; calixarenes of formula (I) wherein: L is &lsqb;&mdash;CH,&mdash;&rsqb; or &lsqb;&mdash;O&mdash;CH,&mdash;O&mdash;&rsqb; and may be the same or different between each aryl group; R,is H, halogen, or C,C,aliphatic hydrocarbyl group, C,C,aryl group, C,C,hydrocarbyaryl group, any of which may optionally be substituted by one or more halo or oxo groups or interrupted by one or more oxo groups, and R,may be the same or different on each aryl group; R,comprises an optionally protected carboxy group; two groups out of R,, R,, and R,are H; the one group out of R,, R,, and R,not being H comprises an amide group. The amide group may be linked to a second calixarene to form a dimer. Also disclosed are methods of use of such calixarenes for the purposes of metal sequestration, especially of lanthanides and actinides. Also disclosed are calixarene dimer derivatives of the calixarenes of the invention. Also disclosed are processes for preparing the calixarenes and dimers.

Growing community of inventors

Reading, United Kingdom

Graeme Peter Nicholson