University of Glasgow

Graeme Milligan

Dominic P Behan

Edward Stephen Rees

The invention provides materials and methods relating to G-protein coupled receptor (GPCR) oligomers. Complexes of two or more GPCRs associated with G-proteins are provided. Also provided are fusion proteins comprising a GPCR and a G-protein, nucleic acids, expression vectors and host cells. Methods of producing the complexes and fusion proteins of the invention are also provided.

Materials and methods relating to G-protein coupled receptor oligomers

The present invention relates to receptor/reporter fusion protein based assays for detecting the effect test compounds have on a particular membrane receptor, as well as to receptor/reporter fusion proteins for use in such assays and compounds identified by the assays as having interesting/useful effects. Suitable membrane receptors are growth factor receptors, cytokine receptors, ion channels and integrins including any subtypes, mutants, homologs and chimeric forms of such receptors. The assay may be to study G-protein coupled receptors (GPCRs).

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Glasgow, United Kingdom

Graeme Milligan