Ctxt Pty Limited

Graeme Irvine Stevenson

Paul Anthony Stupple

Michelle Ang Camerino

Scott Raymond Walker

Benjamin Joseph Morrow

Richard Charles Foitzik

Ylva Elisabet Bergman

H Rachel Lagiakos

John Feutrill

A compound of formula (I), wherein Ris selected from (i) H, (ii) Ccycloalkyl, (iii) Cheterocyclyl optionally substituted with a group selected from: methyl and ester, and (iv) linear or branched Calkyl optionally substituted with a group selected from: alkoxy, amino, amido, acylamido, acyloxy, alkyl carboxyl ester, alkyl carbamoyl, alkyl carbamoyl ester, phenyl, phosphonate ester, Cheterocyclyl optionally substituted with a group selected from methyl and oxo, and a naturally occurring amino acid, optionally N-substituted with a group selected from methyl, acetyl and boc; Ais CRor N; Ais CRor N; Ais CRor N; Ais CRor N; where no more than two of A, A, A, and Amay be N; one or two of R, R, R, and R, (if present) are selected from H, F, Cl, Br, Me, CF, cyclopropyl, cyano, OMe, OEt, CHOH, CHOMe and CHNMe; the remainder of R, R, R, and R, (if present) are H; Y is O, NH or CH; Ris selected from: (RYA) and (RYB).

Substituted condensed thiophenes as modulators of sting

A compound of formula I wherein: n is 1 or 2: p is 0 or 1; Ris optionally one or more halo or methyl groups; Rand Rare independently selected from the group consisting of: (i) F; (ii) H; (iii) Me; and (iv) CHOH; Rand Rare independently selected from the group consisting of: (i) F; (ii) H; (iii) Me; and (iv) CHOH; Rand Rare independently selected from H and Me; Ris either H or Me; Ris either H or Me; Rand Rare independently selected from H and Me; A is either (i) optionally substituted phenyl; (ii) optionally substituted naphthyl; or (iii) optionally substituted Cheteroaryl. 

Tetrahydroisoquinoline derived PRMT5-inhibitors

Growing community of inventors

Victoria, Australia

Graeme Irvine Stevenson