Pioneer Hi-bred International, Inc.

Grace M St Clair

William James Gordon-Kamm

Keith S Lowe

Christopher Jay Scelonge

David J Peterson

Bing-Bing Wang

A variety of methods and compostions are provided, including methods and compositions for targeted modification of a specific target site in a cell or organism, methods for integrating polynucleotides of interest, methods to assess promoter activity, directly select transformed organisms, minimize or eliminate expression resulting from random integration into the genome of an organism, such as a plant, remove polynucleotides of interest, combine multiple transfer cassettes, invert or excize a polynucleotide, silence a gene, and identify and/or characterize transcriptional regulating regions. The methods involve the introduction of a cell proliferation factor and a double-strand break-inducing enzyme into an organism.

Growing community of inventors

DES MOINES, IA, United States of America

Grace M St Clair