Gilead Sciences, Inc.

Relypsa, Inc.

Grace Huynh

YongQi Mu

Scott J Hecker

Paul Mansky

Eric F Connor

Michael James Cope

Qi Liu

Kalpesh N Biyani

Jun Shao

David E Bergbreiter

Martin Gerald Teresk

Deidre Madsen

Shinji Fujimori

Faleh Salaymeh

Angela Lee

Jared Wayne Evans

Elizabeth Goka

Inez Lees

Hongmin Zhang

Jordan Kopping

Xinnan Zhang

The present invention provides crosslinked amine polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercholesteremia, diabetes, pruritus, irritable bowel syndrome-diarrhea (IBS-D), bile acid malabsorption, and the like.

Amine polymers for use as bile acid sequestrants

The present invention provides a crosslinked amine and amide polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercholesteremia, diabetes, pruritis, irritable bowel syndrome-diarrhea (IBS-D), bile acid malabsorption, and the like.

Crosslinked polyvinylamine, polyallylamine, and polyethyleneimine for use as bile acid sequestrants

The present disclosure provides processes for the preparation of a compound of Formula I: which is useful as an antiviral agent. The disclosure also provides compounds that are synthetic intermediates to compounds of formula.

Synthesis of an antiviral compound

Growing community of inventors

San Francisco, CA, United States of America

Grace Huynh