Kyoto University

Toray Industries, Inc.

Japan Science and Technology Agency

Nagoya City University

Gozoh Tsujimoto

Satoko Kozono

Akira Myomoto

Hitoshi Nobumasa

Yoshinori Tanaka

Osamu Ogawa

Hideo Akiyama

Yutaka Shimada

Osamu Nomura

Shiori Tomoda

Masaji Ishiguro

Fumiaki Sato

Kazuharu Shimizu

Masakazu Toi

Takayoshi Suzuki

Naoki Miyata

Takayuki Ueno

Yasushi Okuno

Kei Taneishi

Akira Hirasawa

Yoshiyuki Takahara

Mie Hata

Zhipeng Wang

Eijiro Nakamura

This invention relates to a composition and a method for prediction of a response to Trastuzumab therapy in a breast cancer patient, and more specifically, a composition, a kit, a DNA chip, and a method for predicting a response to Trastuzumab therapy by using polynucleotides each comprising a nucleotide sequence represented by any of SEQ ID NOs: 1 to 9, 11 to 19, and 21 to 23 in the Sequence Listing or a nucleotide sequence derived therefrom by substitution of u with t, mutants thereof, derivatives thereof, or fragments thereof comprising at least 16 continuous nucleotides, or a polynucleotide comprising a complementary sequence thereof, and using an increase or decrease in Her2 protein expression level as an indicator.

Method for predicting response to trastuzumab therapy in breast cancer patients

A data processing method for an estimation of compound-protein interaction using both chemical substance information, such as a chemical property of the compound, and biological information, such as sequence information of genes to rationally and efficiently screen compounds. First space representing space coordinates of a first chemical substance group and second space representing space coordinates of a second chemical substance group are defined, and the first chemical substance group is characterized by a first characteristic amount and the second chemical substance group is characterized by a second characteristic amount, and map transformation of the coordinates of the first space and the coordinates of the second space results in the solution so as to increase the correlation between the first space and the second space using a multivariable analysis technique or a machine learning method.

Estimation of protein-compound interaction and rational design of compound library based on chemical genomic information

This invention relates to a composition, kit, or DNA chip for use in diagnosis of esophageal cancer, which comprises a plurality of polynucleotides selected from the group consisting of polynucleotides whose expression levels are varied in esophageal cancer tissues obtained from esophageal cancer patients when compared with cancer-free esophageal tissues obtained from esophageal cancer patients, mutants thereof, and fragments thereof, and to a method for detecting esophageal cancer using the composition, kit, or DNA chip.

Method for diagnosing esophageal cancer

Disclosed is a novel aralkyl carboxylic acid compound which has an agonistic activity on GPR-120 and/or GPR-40, particularly GPR-120, and is therefore useful as an appetite regulator, an anti-obesity agent, a therapeutic agent for diabetes, a pancreatic beta differentiating cell growth enhancer, a therapeutic agent for metabolic syndrome, a therapeutic agent for a gastrointestinal disease, a therapeutic agent for a neuropathy, a therapeutic agent for a mental disorder, a therapeutic agent for a pulmonary disease, a therapeutic agent for a pituitary hormone secretion disorder or a lipid flavoring/seasoning agent. The aralkyl carboxylic acid compound is represented by the general formula (I). (I) wherein the ring Q represents a pyridyl or the like; Rrepresents a Calkyl group or the like; Rrepresents a hydrogen atom, a Calkyl group or a Calkoxy group; m and n independently represent an integer of 1 to 5; and X represents an oxygen atom, a sulfur atom or &#x2014;NR&#x2014; [wherein Rrepresents a hydrogen atom or a Calkyl group]. 

G-protein-conjugated receptor agonist

This invention relates to a composition, kit, or DNA chip comprising polynucleotides and antibodies as probes for detecting, determining, or predicting the presence or metastasis of esophageal cancer, and to a method for detecting, determining, or predicting the presence or metastasis of esophageal cancer using the same.

Growing community of inventors

Kyoto, Japan

Gozoh Tsujimoto