Flodesign Sonics, Inc.

Goutam Ghoshal

Bart Lipkens

Jason Dionne

Walter M Presz, Jr

Kedar C Chitale

Brian Dutra

Rudolf Gilmanshin

Benjamin Ross-Johnsrud

Louis Masi

Rui Tostoes

Chris Leidel

A closed and modular fluidic system composed of one or more acoustic elements and cell processing reagents. The system employs a cellular manufacturing process for producing cell and gene therapy therapeutics.

Cell therapy processes utilizing acoustophoresis

Multi-stage acoustophoretic devices for continuously separating a second fluid or a particulate from a host fluid are disclosed. Methods of operating the multi-stage acoustophoretic devices are also disclosed. The systems may include multiple acoustophoretic devices fluidly connected to one another in series, each acoustophoretic device comprising a flow chamber, an ultrasonic transducer capable of creating a multi-dimensional acoustic standing wave, and a reflector. The systems can further include pumps and flowmeters.

Concentration and washing of particles with acoustics

Therapeutic cell washing, concentration, and separation utilizing acoustophoresis

Acoustophoretic devices and methods for concentrating targeted biological cells in a reduced volume using multi-dimensional acoustic standing waves are disclosed. The methods include flowing a mixture of a host fluid and the biological cells through an acoustophoretic device. The acoustophoretic devices include an inlet, an outlet, and a flow chamber having an ultrasonic transducer-reflector pair. Biological cells, such as T cells, are separated from a host fluid for utilization in allergenic or autologous cell therapies. The disclosed devices and methods are capable of concentrating biological cells to at least 100 times their original cell concentration. The disclosed methods and devices are further capable of decreasing an original feed volume to a final concentrated volume that is less than one percent of the original feed volume.

System for generating high concentration factors for low cell density suspensions

Growing community of inventors

South Grafton, MA, United States of America

Goutam Ghoshal