Lupin, Inc.

Gourhari Jana

Neelima Sinha

Venkata Poornapragnacharyulu Palle

Rajender Kumar Kamboj

Navnath Popat Karche

Ajay Ramchandra Tilekar

Sanjay Pralhad Kurhade

Sanjay Kumar Jain

Sudershan Kumar Arora

Anil Kashiram Hajare

Rakesh Kumar Sinha

Shridhar Keshav Adurkar

Shankar Ajay

Sachchidanand Sachchidanand

Ram Shankar Upadhayaya

Gagan Kukreja

Arun Rangnath Jagdale

Disclosed is a compound of formula I: wherein Z, m and R-Rare as described herein, as a modulator of nicotinic acetylcholine receptors particularly the &#x3b1;7 subtype, in a subject in need thereof, as well as analogues, prodrugs, isotopically substituted analogs, metabolites, pharmaceutically acceptable salts, polymorphs, solvates, isomers, clathrates, and co-crystal thereof, for use either alone or in combinations with suitable other medicaments, and pharmaceutical compositions containing such compounds and analogues. Also disclosed are a process of preparation of the compounds and the intended uses thereof in therapy, particularly in the prophylaxis and therapy of disorders such as Alzheimer's disease, mild cognitive impairment, senile dementia, and the like.

Heteroaryl derivatives as alpha7 nAChR modulators

Disclosed are compounds of formula (I), their tautomeric forms, stereoisomers, and pharmaceutically acceptable salts thereof, wherein R-R, R, R, A, M, n, and p are as defined in the specification, pharmaceutical compositions including a compound, tautomer, stereoisomer, or salt thereof, and methods of treating or preventing diseases or disorders, for example, cancer, that are amenable to treatment or prevention by inhibiting the PARP enzyme of a subject. 

Tetrahydroquinazolinone derivatives as PARP inhibitors

Disclosed is a compound of formula (I) wherein 'a' and R-Rare as described herein, as a modulator of nicotinic acetylcholine receptors particularly the &#x3b1;7 subtype, in a subject in need thereof, as well as analogs, prodrugs, isotopically substituted analogs, metabolites, pharmaceutically acceptable salts, polymorphs, solvates, isomers, clathrates, and co-crystal thereofs, for use either alone or in combinations with suitable other medicaments, and pharmaceutical compositions containing such compounds and analogs. Also disclosed are a process of preparation of the compounds and the intended uses thereof in therapy, particularly in the prophylaxis and therapy of disorders such as Alzheimer's disease, mild cognitive impairment, senile dementia, and the like. 

Pyrrole derivatives as nicotinic acetylcholine receptor modulators for use in the treatment of neurodegenerative disorders such as alzheimer's and parkinson's disease

Disclosed is a compound of formula (I), wherein Z, m and R-Rare as described herein, as a modulator of nicotinic acetylcholine receptors particularly the &#x3b1;7 subtype, in a subject in need thereof, as well as analogs, prodrugs, isotopically substituted analogs, metabolites, pharmaceutically acceptable salts, polymorphs, solvates, isomers, clathrates, and co-crystal thereof, for use either alone or in combinations with suitable other medicaments, and pharmaceutical compositions containing such compounds and analogs. Also disclosed are a process of preparation of the compounds and the intended uses thereof in therapy, particularly in the prophylaxis and therapy of disorders such as Alzheimer's disease, mild cognitive impairment, senile dementia, and the like. 

Novel pyrrole derivatives of formula (I) and their pharmaceutically acceptable acid addition salts having superior antimycobacterial activity against clinically sensitive as well as resistant strains ofas well as having lesser toxicity compared to known compounds. The use of the novel compounds of formula (I) for treatment of latent tuberculosis including Multi Drug Resistant Tuberculosis (MDR TB). The methods for preparation of the novel compounds, pharmaceutical compositions containing the novel compounds and method of treating MDR TB by administration of compounds of formula (I).

Pyrrole derivatives as antimycobacterial compounds

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Pune, India

Gourhari Jana