Forma Therapeutics, Inc.

Pfizer Corporation

Goss S Kauffman

Kenneth W Bair

Matthew W Martin

David S Millan

Adam Charles Talbot

Shawn E R Schiller

George P Luke

Torsten Herbertz

Katherine J Kayser-Bricker

Mark Joseph Tebbe

Richard D Connell

John Charles Kath

Samit Kumar Bhattacharya

Jinshan Michael Chen

Joel Morris

Blaise S Lippa

The present invention relates to inhibitors of bromo and extra terminal (BET) bromodomains that are useful for the treatment of cancer, inflammatory diseases, diabetes, and obesity, having Formula I: wherein W, X, Y, Z, R, R, R, and Rare as described herein.

Tetrahydroquinoline compositions as BET bromodomain inhibitors

The present invention relates to inhibitors of bromo and extra terminal (BET) bromodomains that are useful for the treatment of cancer, inflammatory diseases, diabetes, and obesity, having Formula (I): wherein X, Y, Z, R, R, Rand Rare defined herein.

Benzopiperazine compositions as BET bromodomain inhibitors

Tetrahydroquinoline compositions as bet bromodomain inhibitors

The present invention relates to inhibitors of bromo and extra terminal (BET) br'omodomains that are useful for the treatment of cancer, inflammatory diseases, diabetes, and obesity, having Formula (I): wherein X, Y, Z, R, R, Rand Rare defined herein.

The invention relates to compounds of formula 1 and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R, R, R, R, N, Z, A, m and p are as defined herein. The invention also relates to methods of treating abnormal cell growth in mammals by administering the compounds of formula 1 and to pharmaceutical compositions for treating such disorders which contain the compounds of formula 1. The invention also relates to methods of preparing the compounds of formula 1.

Substituted heterocylces for the treatment of abnormal cell growth

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Ledyard, CT, United States of America

Goss S Kauffman