Yamasa Shoyu Kabushiki Kaisha

Goro Motoki

Hiroshi Yoshino

Toshihisa Kawahara

Kazuo Uchida

Morio Suzuki

Takashi Nagata

S-adenosyl-L-methionine compositions stabilized against decomposition of S-adenosyl-L-methionine comprising S-adenosyl-L-methionine, a sulfuric acid equivalent and a nucleoside sulfate, which are produced from a solution comprising the three essential components in an aqueous solvent by, for example, adding thereto a water-miscible organic solvent thereby to precipitate the composition (process A) and/or by evaporating the aqueous solvent off the solution (process B).

S-Adenosyl-L-methionine compositions and production thereof

A stabilized dry S-adenosyl-L-methionine preparation is obtained by incorporating about 1 - 10 parts by weight of lithium in the form of a salt with 100 parts by weight of S-adenosyl-L-methionine or a low-toxicity salt thereof. According to the invention, instability of S-adenosyl-L-methionine or a salt thereof is substantially eliminated. The stabilized dry preparation is very useful as medical drugs and reagents for biochemical research.

Stabilized S-adenosyl-L-methionine preparations

N.sup.2,2'-O-dibutyrylguanosine-3',5'-cyclic phosphate or a salt thereof is stabilized by adjusting the moisture content thereof to 3 percent or less by weight.

Stabilized N.sup.2,2-O-dibutyrylguanosine-3,5-cyclic phosphate and salts

Crystalline N.sup.6,2'-O-dibutyryl-adenosine-3',5'-cyclic monophosphate monosodium salt (DB.sub.c -AMP-N.sub.a), and a process for producing the same which may comprise the step of causing at least one solvent selected from an ether, ketone, and an ester, constituting a crystallizing organic solvent, to contact an alcoholic solution, aqueous alcoholic solution, or a simple aqueous solution of DB.sub.c -AMP-N.sub.a or may comprise the step of dissolving crude crystalline or amorphous DB.sub.c -AMP-N.sub.a in a mixture of an alcoholic solvent and the crystallizing organic solvent.

Growing community of inventors

Choshi, Japan

Goro Motoki