Otsuka Pharmaceutical Company, Limited

Goro Miyakoda

Toyoki Mori

Hiroshi Yamashita

Muneaki Kurimura

Takayuki Matsuzaki

Isao Takemura

Fujio Tabusa

Masatoshi Chihiro

Kazuyoshi Kitano

Hisashi Nagamoto

Shinobu Sueyoshi

Ayako Hashimoto

Takashi Imaizumi

The present invention provides a pharmaceutical composition for promoting angiogenesis, which has an angiogenesis promoting action even in a vascular culturing system without effect of microcirculation. A pharmaceutical composition for promoting angiogenesis of the present invention comprises at least one compound selected from a group consisting of a piperidine compound represented by the general formula (1) or salts thereof: (wherein R represents a benzoyl group which may have, as substituents on the phenyl ring, 1 to 3 groups selected from a group consisting of an amino group, which may have a lower alkanoyl group, and a lower alkyl group; Rrepresents a hydrogen atom or a lower alkyl group; and Rrepresents a phenyl lower alkyl group). 

Pharmaceutical composition for promoting angiogenesis

The present invention provides an agent for inhibiting cytokine production or cell adhesion, comprising at least one compound selected from the group consisting of thiazole derivatives represented by the following general formula: [wherein Ris a phenyl group which may have a lower alkoxy group(s) as a substituent(s) on the phenyl ring, and Ris a group represented by the following general formula: (wherein R's, which may be the same or different, are each a carboxyl group, a lower alkoxy group or the like) or the like] and salts thereof.

Agent for inhibition of cytokine production and agent for inhibition of cell adhesion

The present invention provides an agent for inhibiting cytokine production or cell adhesion, comprising at least one compound selected from the group consisting of thiazole derivatives represented by the following general formula:

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Matsushige, Japan

Goro Miyakoda