Kuraray Co., Ltd.

Goro Asanuma

Manzo Shiono

Hideki Matsuda

Yoshin Tamai

Tomoya Kuwayama

Shigeki Kikuyama

Takanobu Shin

Takashi Sugioka

Ken-ichi Koyakumaru

Koichi Kanehira

Toshimichi Mitani

Makoto Nakazawa

Shigeo Ohzono

Kei Miyoshi

Kazuya Takaki

Shinichi Inoue

Shigeo Oozono

Yoichi Satake

An industrially advantageous method for producing a high purity terminal olefin is disclosed, comprising the steps of (a) contacting a mixture comprising a terminal olefin represented by formula (1): and one or more corresponding internal olefins as impurities, with a brominating agent in the presence of water or an alcohol, to convert the internal olefin(s) to compound(s) having a higher boiling point than the terminal olefin; and (b) purifying the terminal olefin by distillation from the reaction mixture.

Method for producing high purity terminal olefin compound

2-Sulfonylpyridine derivatives can be industrially produced efficiently by reacting a sulfonyl cyanide derivative with an &agr;,&bgr;-unsaturated carbonyl compound and a 2-&lcub;&lsqb;(2-pyridyl)methyl&rsqb;thio&rcub;-1H-benzimidazole skeleton can be formed in one step in a good yield by reacting this type of the 2-sulfonylpyridine derivative with a 2-methylthio-1H-benzimidazole derivative in the presence of an organolithium compound.

4-chloro-3,5-dimethyl-2-sulfonyl pyridines

Method for producing pyridine derivatives

A pyridine alcohol derivative represented by General Formula III

Process for the preparation of 2-chloro-5-chloromethyl-1,3-thiazole

2-Sulfonylpyridine derivatives can be industrially produced efficiently by reacting a sulfonyl cyanide derivative with an &agr;, &bgr;-unsaturated carbonyl compound and a 2-&lcub;&lsqb;(2-pyridyl)methyl&rsqb;thio&rcub;-1H-benzimidazole skeleton can be formed in one step in a good yield by reacting this type of the 2-sulfonylpyridine derivative with a 2-methylthio-1H-benzimidazole derivative in the presence of an organolithium compound.

Method for producing 2-sulfonylpyridine derivatives and method for producing 2-&lcub;&lsqb;(2-pyridyl)methyl&rsqb;thio&rcub;-1H-benzimidazole derivatives

A cyclopropylacetylene derivative of the formula (V):

Process for the preparation of cyclopropylacetylene derivatives

Process for preparing halogenopyridine derivatives

A pyridine alcohol derivative represented by General Formula III ##STR1## (where A represents a divalent organic group which may contain one to three oxygen atoms, nitrogen atoms and/or sulfur atoms, wherein A may form a 5-, 6-, 7-, or 8-membered ring together with two bonded carbon atoms, where said ring may form a condensed ring with one or more additional rings; R.sup.5 represents a hydrogen atom, --CHR.sup.1 R.sup.2, or an alkenyl group, an aryl group or an aralkyl group which may be substituted; R.sup.1 and R.sup.2 each independently represent a hydrogen atom or a hydrocarbon group which may be substituted; and R.sup.6 represents a hydrogen atom, an alkyl group, an alkenyl group, an aryl group or an aralkyl group which may be substituted), is produced by:

Intermediates for producing pyridine derivatives

According to the present invention, provided are

According to the present invention, a process for the preparation of a cyclopropylacetylene derivative represented by the following formula (III): ##STR1## is provided, which comprises reacting a cyclopropylacrylic acid derivative represented by the following formula (I): ##STR2## with a halogenating agent to obtain a halogenocyclopropylpropionic acid derivative represented by the following formula (II): ##STR3## and reacting the halogenocyclopropylpropionic acid derivative with a base.

An all trans-form polyprenol is obtained by;

Process for producing all trans-form polyprenols

A process for producing (.+-.)-2,2,2,5a-tetramethyl-1-(carboxymethyl)-2-hydroxydecalin, comprising the steps of allowing a carbonate of dihydro-.beta.-vinyl-ionol to react with carbon monoxide in the presence of a palladium catalyst to form .beta.-monocyclohomofarnesic acid, cyclizing said .beta.-monocyclohomofarnesic acid in the presence of an acid catalyst to form (.+-.)-norambreinolid, and hydrolyzing said (.+-.)-norambreinolide to form (.+-.)-2,5,5,8a-tetramethyl-1-(carboxymethyl)-2-hydroxydecalin.

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Okayama, Japan

Goro Asanuma