University College London

Stanmore Implants Worldwide Limited

Biomet UK Limited

Quy Biosciences Limited

Recellerate, Inc.

Gordon William Blunn

Paul Unwin

Justin Peter Cobb

Allen Goodship

Peter Stanley Walker

David Barrett

William Muirhead-Allwood

Jay Meswania

Hilali Noordeen

Robert John Andrew Bigsby

Xinhua Wu

Christos Pappas

Roger Kenneth Whealands Smith

Kenneth Gregory McGarrell

Poul T Nielsen

Allen Edward Goodship

Michael Herbert Jacobs

Mark Andrew Ashworth

John Perry

Kenneth Gregory Mcgarrell

Roger Kenneth Smith

Chritos Pappas

Poul T Neilsen

An intracorporeal portion of a percutaneous device for a joint disarticulation prosthesis or joint replacement prosthesis, the intracorporeal portion having an extracorporeal portion or having means for rigidly coupling directly to an extracorporeal portion, the extracorporeal portion being for location exterior to the skin, the intracorporeal portion having an articulating component for articulating with an articulating surface, wherein the articulating component is intracorporeal when installed in a human or animal subject.

Percutaneous device

A femoral neck prosthesis () with a cross-section defined by a perimeter comprising: first and second arcuate portions () disposed opposite one another; and first and second substantially straight portions () disposed opposite one another and in between the first and second arcuate portions, wherein the first and second straight portions are non-parallel with respect to one another.

Femoral neck prosthesis

Method of installing a percutaneous device

A transcutaneous prosthesis which includes a first component shaped for implantation into a bone, a second component intended for location between the bone and the skin, the second component having a surface treatment for stimulation of fibroblastic cell proliferation and attachment of epithelial cells, and a third component intended for location exterior to the skin surface having a low surface energy which deters bacterial adhesion.

Transcutaneous prosthesis

A transcutaneous prosthesis includes a first component shaped for implantation into a bone, the first component including flutes or grooves on a surface thereof for deterring rotation of the prosthesis within a bone; a second component adapted for location between the bone and the skin, the second component having a surface treatment for stimulation of fibroblastic cell proliferation and attachment of epithelial cells; and a third component adapted for location to extend from the skin surface and is adapted to extend directly from the skin surface in use, the third component having a coating of a non-stick material on an outer surface thereof, the coating having a surface energy that is lower than a surface energy of the first and second components and which is low enough to deter bacterial adhesion.

A method of treating a natural soft skeletal tissue injury in a patient the method comprising administering to the patient a composition of mesenchymal stem cells in liquid suspension enriched compared to the natural source of said cells, or tenocytes derived therefrom. The method is particularly suited to the regeneration of tendons in competitive mammals, such as the superficial digital flexor tendon of the horse.

Pharmaceutical kits comprising mesenchymal stem cells

A method of installing a transcutaneous prosthesis which includes a first component, a second component adapted for location between the bone and the skin, the second component having a surface treatment for stimulation of fibroblastic cell proliferation and attachment of epithelial cells and a third component adapted for location to extend from the skin surface and the third component having an outer surface. The outer surface of the third component has a surface energy that is lower than a surface energy of at least the first component and which is low enough to deter bacterial adhesion. The method includes attaching the first component to a bone such that a transition from the second component to the third component is essentially at the surface of the skin and the third component extends from the skin surface when the first component is attached to a bone.

Method of installing a transcutaneous prosthesis

A surgical implant comprises a core region and a porous surface region extending over at least part of the core region. The surface region has a predetermined pore volume fraction. A method of manufacturing a surgical implant comprises: (i) loading metallic powder having a predetermined particle size distribution around a pre-formed core in a sealable capsule; (ii) reducing pressure within the capsule to a predetermined pressure below atmospheric pressure; (iii) pressurising the capsule with a process gas to a predetermined pressure higher than the predetermined pressure of step (ii); (iv) sealing the capsule; (v) heating the pressurised sealed capsule at an elevated temperature and an elevated pressure for a predetermined time to produce an implant precursor; (vi) cooling the sealed capsule, and; (vii) heating the implant precursor for a predetermined time at an elevated temperature and a predetermined pressure below atmospheric pressure, whereby to generate porosity in the implant precursor.

Surgical implant

A transcutaneous prosthesis is disclosed comprising a first component () shaped for implantation into a bone (), a second component () intended for location between the bone () and the skin, and a third component () intended for location exterior to the skin surface, having a low surface energy which deters bacterial adhesion. The second component () may carry an adhesion-promoting protein.

A surgical distraction device is provided for applying extending or tensioning force non-invasively to a patient's skeleton or to an implant which comprises anchoring means for attaching first and second components of the device to a bone or to adjoining bones, said components being connected by a linkage of an extendible length, a magnet connected to the linkage via a reduction gearbox and actuating means located externally of the patient for generating a moving or varying electro-magnetic field, thereby causing the magnet to rotate and the linkage to be extended.

Surgical distraction device

A prosthetic joint for replacing a natural joint in a body includes a first prosthetic component of the prosthetic joint which, when implanted into a first resected bone of the natural joint has a junction between the implanted component and the bone. The joint further includes a second prosthetic component of the prosthetic joint which, when implanted into an adjacent resected bone of the natural joint, articulates with the first component. A microporous membrane surrounds the first prosthetic component and is secured to the first prosthetic component and, when implanted in a body, is secured to bone surrounding said first prosthetic component, thereby sealing the junction against ingress of particles, but permitting liquids to pass through said membrane without restricting articulation of the joint.

Growing community of inventors

Royston, United Kingdom

Gordon William Blunn