Adir Et Compagnie

Les Laboratoires Servier

Centre National De La Recherche Scientifique

Les Laboratories Servier

Gordon Tucker

Alain Pierre

Ghanem Atassi

Massimo Sabatini

Guillaume De Nanteuil

Jacqueline Bonnet

Patrick Casara

Georges Remond

John Hickman

Thierry Le Diguarher

Nicolas Guilbaud

Joseph Paladino

Pierre Renard

Daniel-Henri Caignard

Stephen Hanessian

François Lefoulon

Françoise Perron-Sierra

Luc Demuynck

Alain Benoist

Gilbert Dorey

Philippe Pastoureau

Stéphanie Lerondel

Hubert Grandon

Jean-Marie Delbos

Dominique Saint-Dizier

Guillaume Reveillon

Anne Marie Chollet

Alain Lepape

Compounds of formula (I) in which: &#x3e;R is a linear or branched (C-C) alkyl, &#x3e;L is a spacer group, &#x3e;A is a diagnostic agent, and &#x3e;m is equal to 1 or 2.

Imaging agents, process for the preparation thereof and pharmaceutical compositions containing same

Vitronectin receptor antagonist bicyclic compounds, preparation method and compositions containing same

Metalloprotease inhibitors

Cycloheptene compounds

The invention concerns a compound of formula (I) wherein: n is equal to 0 or 1; R , R , R , R represent a hydrogen or an alkyl group, or R and R together form a cycloalkyl group; R represents a hydrogen, an alkyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl, hetereoalkylalkyl, hetereocycloalkyl, hetereocycloalkylalkyl group (all optionally substituted), or a &mdash;CO&mdash;R group; and R represents R or OR or NR R , with R representing an aryl, arylalkyl, heteroaryl or heteroarylalkyl, heterocycloalkyl, heterocycloalkylalkyl group (all optionally substituted), and R representing an alkyl, aryl, arylalkyl, heteroaryl or heteroarylalkyl (all optionally substituted); or R and R form with the nitrogen atom and the Z group bearing them a saturated monocyclic, bicyclic or tricyclic group, partially unsaturated or unsaturated, with 5 to 16 chain links containing 1 to 7 heteroatoms and optionally substituted; R represents a hydrogen atom or a hydroxy group, and in the latter case R , R , R , R are independently selected among hydrogen and alkyl; Z represents a hydroxy, alkoxy, alkenyloxy, benzyloxy group or a NH&mdash;OR group; X represents a sulphur, a SO, SO group (in those cases where R and R are different from an alkyl) or a group &mdash;CO&mdash;O&mdash; (in which case R and R form a cycloalkyl group), or X represents an oxygen atom; W represents a W &mdash;(A) or W &mdash;B&mdash;W &mdash;(A) group wherein W and W represent an aryl or heteroaryl group, A is a standard substituent of aromatic cycles, B a bond, an oxygen or an alkylene, alkenylene, alkynylene group, and p is an integer ranging between 0 and 5; T and T represent a bond or an alkylene, alkenylene, or alkynylene group. The invention is useful for preparing medicines.

Carboxylic and hydroxamic acid compounds inhibiting metalloproteases, method for preparing same and pharmaceutical compositions containing them

Compound of formula (I): ##STR1## in which: m represents an integer from 1 to 4 inclusive, and n and p an integer from 0 to 4 inclusive,

Metalloproteinase inhibitors

A compound selected from those of formula (I): ##STR1## wherein: R.sub.1 represents optionally substituted alkyl, acyl, cycloalkyl, aryl, aminocarbonylalkyl, or heterocycle,

Hydroxamic acid compounds

Compound of formula (I): ##STR1## in which: m, n, which are identical or different, represent 0, 1 or 2,

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Paris, France

Gordon Tucker