The Johns Hopkins University

University of Virginia Patent Foundation

Gordon Tomaselli

David A Kass

Chao-Wei Hwang

Peter V Johnston

Robert G Weiss

Gary Gerstenblith

Steven P Schulman

Jonathan Kirk

Jeffrey A Brinker

Zhiyong Xia

Virginia E Bogdan

George L Coles

J Randall Moorman

Jason J Benkoski

Douglas E Lake

Deeptankar Demazumder

The invention provides methods related to improving heart function.

Methods for improving heart function

Certain embodiments according to the present invention provide sleeve devices suitable for a wide range of therapeutic uses. In accordance with certain embodiments, the therapeutic sleeve device includes a nanofiber fabric assembly, which defines a plurality of pores, and at least one layer of cells embedded in the nanofiber fabric assembly.

Cell impregnated sleeve for paracrine and other factor production

A method for promoting healing of tissue by delivering a bioreactor into a subject is provided. The bioreactor is an enclosed housing with paracrine factor producing cells enclosed within the housing. The housing is impermeable to the paracrine factor producing cells, impermeable to immunological cells outside of the housing, and permeable to paracrine factors produced by the paracrine factor producing cells. The paracrine factors produced by the paracrine factor producing cells are released out of the housing to promote healing of the tissue.

Methods for promoting healing of tissue

A method of determining health and mortality includes obtaining a ventricular activation (RR) time series from a subject for multiple temporal intervals. The method also includes calculating a cardiac entropy in the RR time series over the temporal intervals using coefficient of sample entropy (COSEn). Additionally, the method includes comparing the cardiac entropy between the intervals to determine health and mortality. The absolute and relative changes in entropy over a patient's follow up period provide dynamic information regarding health and mortality risk. The determination of health and mortality can then be used to create a treatment plan for the subject.

Ventricular activation (RR) entropy change as a predictor of sudden cardiac death in cardiac resynchronization therapy patients

Growing community of inventors

Lutherville, MD, United States of America

Gordon Tomaselli