Pharmagene Laboratories Limited

Biowisdom Limited

Gordon Smith Baxter

Stephen Philip Gardner

Robin Duncan Hill

Conor McMenamin

Nicholas Tilford

Nicholas Sean Tilford

Richard A Borman

The invention relates generally to a system and method for creating one or more structured multi-relational ontologies. The invention may include ontologies comprising assertions made up of concept-relationship-concept triplets. The invention may also include predefined sets of concept and relationship types as well as concept type hierarchies and concept-relationship association parameters. The invention may further include properties as concepts, synonyms of concepts as concepts, and documents or parts thereof as concepts.

Creating a multi-relational ontology having a predetermined structure

The present invention relates to the finding that receptors for the neurotransmitter 5-HT of the 5-HT class are located on the human colon, and that their activation potentiates neuronally-mediated responses, and are thus causative in the abnormal motility and pain associated with IBS. The invention provides a method of treatment of IBS which comprises providing to a patient in need of treatment an effective amount of a 5HT2B receptor antagonist which acts on 5HT2B receptors located in the colon of said patient. Such antagonists may be administered in the form of compositions adapted to be delivered to the colon, such as depot formulations and suppositories. Assay methods for the development of compounds for the treatment of IBS are also provided.

Assay method for detecting 5-HT2B antagonists

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Cambridge, United Kingdom

Gordon Smith Baxter