Reference Diagnostics, Inc.

First Light Biosciences, Inc.

Fisher Scientific Company

First Light Diagnostics, Inc.

Straus Holdings Inc.

Gordon Siek

Don Straus

Joseph F Lawlor

Joseph D Musto

Greg Yantz

Damon H DeHart

Sadanand Gite

Ezra Solomon Abrams

Lisa Shinefeld

Teresa H Chan

Damon Dehart

Arleen Chase

Ezra Abrams

The invention provides devices that improve tests for detecting specific cellular, viral, and molecular targets in clinical, industrial, or environmental samples. The invention permits efficient detection of individual microscopic targets at low magnification for highly sensitive testing. The invention does not require washing steps and thus allows sensitive and specific detection while simplifying manual operation and lowering costs and complexity in automated operation. In short, the invention provides devices that can deliver rapid, accurate, and quantitative, easy-to-use, and cost-effective tests.

Kits and devices for detecting analytes

The invention provides an improved method for sensitive and specific detection of target molecules, cells, or viruses. The inventive method uses large area imaging to detect individual labeled targets complexed with a target-specific selection moiety. The invention eliminates wash steps through the use of target-specific selection through one or more liquid layers that can contain optical dye and density agents. By eliminating washes the invention simplifies instrumentation engineering and minimizes user steps and costs. The invention uses sensitive image analysis to enumerate individual targets in a large area, is scalable, and can be deployed in systems ranging in complexity from manual to highly automated.

Method for detecting analytes

Assays, such as immunoassays, and related articles are disclosed.

Analyte binding turbidity assay

Analyte-binding assays, such as iron binding assays, are disclosed. The assays can provide information relating to the serum iron content and/or total iron binding capacity of a sample.

Analyte-binding assay

Methods, reagents and reaction mixtures for determining total iron binding capability is disclosed.

Rapid separation assay for total iron binding capacity

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Somerville, MA, United States of America

Gordon Siek