Advanced Cardiovascular Systems, Inc.

Abbott Cardiovascular Systems, Inc.

Gordon S Stewart

Syed F A Hossainy

Paul M Consigny

Benjamyn Serna

Gina Zhang

Syed Faiyaz Ahmed Hossainy

William Earl Webler, Jr

Lothar W Kleiner

Daniel L Cox

Gene Park

Gustavo D Cipolla

Stephen D Pacetti

Wouter Erik Roorda

Arkady Kokish

Klaus Kleine

Jessica R DesNoyer

Srinivasan Sridharan

Christopher Feezor

Stephen R Dugan

Ty T Hu

Kurt W Scheinpflug

Benny Serna

Bjorn G Svensson

Jeff Royal

Mark A Williams

Nancy Kirsten

Yung-Ming Chen

Yiwen Tang

Deborah L Kilpatrick

Jeffrey T Ellis

Victoria May Gong

Dorrie M Happ

Lisa Weldon

Dorie M Happ

Maricela Kezis

Chandana Bellam

Jin Cheng

Syed FA Hossainy

Systems, devices and methods for eluting an agent at a treatment site are disclosed. The devices include an expandable frame and at least one membrane. The membrane may carry an agent to elute at the treatment site. The membrane may allow blood flow at the treatment site during agent delivery.

Methods and devices for eluting agents to a vessel

A method of coating a stent is presented such that less than 50% of the total amount of 40-O-(2-hydroxyl)ethyl-rapamycin, or an analog or derivative thereof, is released in vivo in a 24 hour period, wherein the method comprises exposing the coating to sufficient temperature to modify the structure of the polymer.

Method of coating a stent with a release polymer for 40-O-(2-hydroxy)ethyl-rapamycin

A composition including a solution suitable for introduction into a blood vessel comprising particles including a treatment agent and a tunable stimuli-responsive polymer. A method including introducing a delivery device into a blood vessel; and introducing a solution into the blood vessel, the solution including particles comprising a treatment agent and a tunable stimuli-responsive polymer. A method including combining a treatment agent and a tunable stimuli-responsive polymer; and forming particles of the combination suitable for delivery through a blood vessel.

Stimuli responsive polyester amide particles

The present invention generally encompasses a medical article, such as a medical device or coating comprising an agent or combination of agents, wherein the agent is distributed throughout a polymeric matrix. The polymeric matrix comprises an agent and a poly(ester amide) having a design that was preselected to provide a predetermined release rate of the combination of agents from the medical article.

Poly(ester amides) for the control of agent-release from polymeric compositions

Methods are disclosed for controlling the morphology and the release-rate of active agent from a coating layer for medical devices comprising a polymer matrix and one or more active agents. The methods comprise exposing a wet or dry coating to a freeze-thaw cycle. The coating layer can be used for controlled delivery of an active agent or a combination of active agents.

Freeze-thaw method for modifying stent coating

Drug-delivery systems such as drug-delivery stents having an anti-proliferative agent such as everolimus and an anti-flammatory agent such as clobetasol are provided. Also disclosed are methods of treating a vascular impairment such as restenosis or vulnerable plaque.

Anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders

The present invention relates to methods of applying a drug&#x2014;polymer coating layer onto an implantable medical device or another substrate, and the use of a choice of solvents to adjust the release of the drug from the coating. The drug to polymer ratio is about 1:1 to 1:3 on a mass basis. The polymer and the drug are hydrophobic.

Methods of application of coatings composed of hydrophobic, high glass transition polymers with tunable drug release rates

A drug-delivery system is provided including at least 100 &#x3bc;g of everolimus and clobetasol, such that the ratio of everolimus to clobetasol is at least 10:1 (w/w) or the amount of everolimus by weight is at least 10 times more than clobetasol. The system can be a stent. Also provided a method of treating restenosis or vulnerable plaque of a blood vessel, the method includes locally administering to a patient a first drug selected from a group consisting of rapamycin (sirolimus), Biolimus A9, deforolimus, AP23572, tacrolimus, temsirolimus, pimecrolimus, zotarolimus (ABT-578), 40-O-(2-hydroxy)ethylrapamycin (everolimus), 40-O-(3-hydroxy)propylrapamycin, 40-O-[2-(2-hydroxy)ethoxy]ethylrapamycin, 40-O-tetrazolylrapamycin and 40-epi-(N1-tetrazolyl)rapamycin, and locally administering to a patient a second drug consisting of clobetasol, wherein the minimum amount of the first drug that is locally administered is 100 &#x3bc;g, and wherein the ratio of the first drug to the second drug is, for example, 10:1 to 100:1 (w/w).

Anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders with an implantable medical device

Provided herein is a method of controlling release rate of a bioactive agent from an implantable medical device comprising a coating, a coating on the implantable device and a method of making the coating.

Piezoelectricity modulated release rate of drug from a coating

A mask for masking a stent during a coating procedure may include a mask body that has a negative pattern or an approximate negative pattern of a stent pattern being masked by the mask body. An apparatus for selectively coating a predetermined portion of a medical article may include a dispenser of a coating composition, a mask, a device for creating a relative movement between the mask and the medical article.

Apparatus for selectively coating a medical article

A method and coating for reducing the release rate of an active agent from an implantable device, such as a stent, is disclosed.

40-O-(2-hydroxy)ethyl-rapamycin coated stent

Drug-delivery stents capable of providing release of two or more drugs such as everolimus and estradiol are provided. The stents can be used for treating a disease such as restenosis and vulnerable plaque.

Drug-delivery stent formulations for restenosis and vulnerable plaque

Growing community of inventors

San Ramon, CA, United States of America

Gordon S Stewart