Astrazeneca Ab

Medimmune Limited

Gordon Moody

Scott A Hammond

Yariv Mazor

Karin Lee

Ryan Gilbreth

Eleanor Clancy-thompson

Michael Overstreet

Maria Letizia Giardino Torchia

Stacy Pryts

Yue Wang

Michael Glen Overstreet

Deepali Malhotra

This disclosure relates to compositions and methods for treating cancer using armored chimeric antigen receptor cells.

Compositions and methods of treating cancer with chimeric antigen receptors

The disclosure relates to binding proteins, including antibodies, that bind to Programmed Death-1 ('PD-1') and T cell immunoreceptor with Ig and ITIM domains (“TIGIT”). The disclosure also provides compositions comprising such binding proteins and nucleic acid molecules encoding such binding proteins. The disclosure further relates to methods of treating a disorder or condition using such binding proteins.

Bispecific PD-1 and TIGIT binding proteins and uses thereof

Growing community of inventors

GAITHERSBURG, MD, United States of America

Gordon Moody