The United States of America As Represented by the Department of Health

The United States of America As Represented by the Secretary of

University of Illinois

Other

National Institutes of Health, a Component of the US Dept. of Health & Human Services

Brigham Young University

Gordon M Cragg

Michael R Boyd

James Brislin McMahon

John H Cardellina, Ii

Kirk R Gustafson

Lewis K Pannell

Yoel Kashman

Richard W Fuller

Doel Soejarto

Laurent A Decosterd

Gerhard Bringmann

John W Blunt

Kirk P Manfredi

Johnson Jato

Ian Parsons

Robert J Gulakowski

Duncan Thomas

Peter M Blumberg

Paul Alan Cox

John A Beutler

Junichi Ishitoya

Nancy A Sharkey

Krik R Gustafson

Owen S Weislow

Ian Parson

John H Cardelina, Ii

The present invention provides novel antiviral compounds, refered to as calanolides, related compounds, and their derivatives, which may be isolated from plants, or derived from compounds from plants, of the genus Calophyllum in accordance with the present inventive method. The compounds and their derivatives may be used alone or in combination with other antiviral agents in compositions, such as pharmaceutical compositions, to inhibit the growth or replication of a virus, such as a retrovirus, in particular a human immunodeficiency virus, specifically HIV-1 or HIV-2.

Calanolide and related antiviral compounds, compositions, and uses thereof

The present invention provides novel antiviral naphthoquinone compounds, which may be isolated from plants of the genus Conospermum or synthesized chemically, in accordance with the present inventive methods. The antiviral naphthoquionone compounds, derivatives thereof, and prodrugs thereof, may be used alone or in combination with other antiviral agents in compositions, such as pharmaceutical compositions, to inhibit the growth or replication of a virus, such as a retrovirus, in particular a human immunodeficiency virus, specifically HIV-1 or HIV-2, in the treatment or prevention of viral infection.

Antiviral naphthoquinone compounds, compositions and uses thereof

Calanolide and related antiviral compounds, compositions, and uses

Antiretroviral naphthoquinone compounds compositions and uses thereof

The present invention provides new antiviral compounds, i.e., michellamines and derivatives and pharmacologically acceptable salts thereof, methods for isolating such antiviral compounds from a plant species of the genus Ancistrocladus, antiviral compositions containing such antiviral compounds, and methods of using such antiviral compounds for treating patients with viral infections. The antiviral compounds of the present invention inhibit the reproduction and cytopathicity of human acquired immunodeficiency viruses.

Process of preparing michellamine compounds

The present invention relates to an antiviral composition and to methods of treating patients with viral infections. The antiviral composition of the present invention comprises prostratin, a phorbol ester derivative, and a pharmaceutically acceptable carrier. The present composition while having antiviral activity does not have substantial tumor promoting activity and does not have other substantial adverse toxicological properties that would preclude its use in antiviral therapy.

Antiviral composition

Calanolide and related antiretroviral compounds, compositions, and uses

Michellamine antiviral agents, compositions, and treatment methods

Growing community of inventors

Bethesda, MD, United States of America

Gordon M Cragg