Baxter International Inc.

Biointerventional Corporation

Other

Biosurgical Corporation

Baxter Healthcare Sa

Cardiva Medical, Inc.

Baxter Healthcare Inc.

Biointerventional Coporation

Gordon Howard Epstein

Mitchell Elliott Levinson

Todd E Lempert

Brian Benjamin Martin

David Mark Taylor

Alan Kirby Plyley

Richard K Spero

Russell James Redmond

Richard M Romley

Adam Hagmann

Atif M Yardimci

Zia Yassinzadeh

Russel James Redmond

Glenn Foy

Philip P Corso, Jr

A device for expansion within a blood vessel having a wall defining a lumen in the body. The device comprises an elongated tubular member having proximal and distal extremities and having a longitudinal axis. An expansile member is carried by the distal extremity of the elongated tubular member and is movable between contracted and expanded configurations. A deformable membrane having proximal and distal outer surfaces at least partially covers the expansile member in the expanded configuration. The proximal and distal outer surfaces have substantially different configurations when the expansile member is in the expanded configuration. Deployment means is carried by the proximal extremity of the elongated tubular member and is coupled to the expansile member for moving the expansile member between the contracted and expanded configurations. A handle assembly is carried by the proximal extremity of the elongated tubular member and coupled to said deployment means.

Expansile device for use in blood vessels and tracts in the body and method

A filling device and method, particularly for two-component sealants such as fibrin sealants, which enables two fluids to be separately and directly filled to the reservoirs of a dual syringe fluid applicator from two storage containers, which can be standardized, sealed, sterilized bottles. The device has a connector which engages with the fluid applicator, is keyed to orient the applicator's fluid reservoirs in a predetermined manner and holds the containers in side-by-side alignment with the applicator. Two fluid conduits whose downward ends may be pointed to pierce seals on the bottles, extend between the applicator and the bottles and can each have a transverse reach to accommodate the girth of the bottles. The bottles may be tilted by the device to enable the conduits to draw maximal fluid from a lowermost point of the bottle. Tilting can be effected by a downward movement of the device supporting the applicator which movement can introduce the fluid conduits into the bottles. A shroud can enclose and seal the bottles and permit the apparatus complete with fluid applicator to be introduced into a sterile environment. Additionally embodiments for use with a single vial are also disclosed.

Direct dual filling device for sealing agents

A process and apparatus for one-step preparation of fibrinogen adhesive by polyethylene glycol-mediated precipitation from plasma are disclosed. The methods and apparatus of the invention permit preparation of autologous fibrinogen adhesive composition from the patient during surgery, and can be applied generally to provide such compositions. Also disclosed are an apparatus and method for application of sealant comprising this fibrinogen adhesive composition.

Method of applying composition to a surface

A filling device for connecting a dispensing instrument having multiple fluid reservoirs to multiple containers is disclosed. More particularly, the present invention discloses a connecting device capable of coupling the individual reservoirs of a dispensing instrument to multiple fluid containers. The apparatus includes a body, a collar extending from the body, a plurality of tubes in fluid communication with a plurality of inlet ports formed in the body, and a hood adapted to simultaneously receive a plurality of containers therein. The containers are positioned within the hood to allow the plurality of tubes to simultaneously and separately draw fluid from the fluid containers and transferring the material into the individual reservoirs of the dispensing instrument.

A sealant applicator suitable for dispensing a coagulable sealant, for example a two-component fibrin sealant mixed in the applicator, employs impulse clearing to remove residual coagulated or coagulating material from the dispensing pathway and mixing chamber, if present. Impulses may be generated by manual application of a clearing member such as a plunger which can enter into the dispensing pathway to engage, dislodge and discharge residuals or can generate a gas impulse to impact the residuals to similar effect. A clearing valve having a clearing port can be operated by movement of the clearing member to provide access to the dispensing pathway.

Sealant applicator and method employing impulse clearing

A multi-component sealant applicator comprises a dual catheter for delivering sealant. Each catheter communicates with one of a pair of fluid sealant agent sources and comprises a mixing volume within the dual catheter for mixing multiple components of a multi-component sealant prior to discharge from a distal end of the catheter and a clearing system to clear undesired material from the mixing volume or the vicinity of the mixing volume, wherein one catheter is mounted for longitudinal movement within the other and the inner catheter is usable as a plunger to remove clogs. The catheter may comprise a reciprocal drive mechanism proximally coupled with the dual catheter to move one catheter longitudinally with respect to the other. The drive mechanism may comprise a ratchet and pawl.

Component mixing catheter

A laparoscopic spray device for selectively applying a multiple component material dispensed from a multiple component material applicator to a surgical site in vivo is disclosed. The device comprises an interface member capable of engaging a multiple component applicator, a body having at least two lumens therein, and a detachable spray tip in fluid communication with the body. The detachable spray tip includes a mixing chamber having at least one flexible mixing member positioned therein which is capable of creating a turbulent flow within a mixing chamber. In addition, the at least one mixing member prevents a back flow of material from the mixing chamber to the at least two lumens. The present invention is particularly useful in remotely applying multiple component tissue adhesives to an internal incision.

Laparoscopic spray device and method of use

The invention provides a handheld, manually operable fluid applicator, particularly suited to the needs of surgeons, for dispensing a multi-component fluid applicator, for example fibrin and thrombin components of a tissue adhesive. A preferred applicator has a body containing reservoirs for the sealants and a detachable dispensing head which can be removed to refill the reservoirs. In the mixing head, the sealant components undergo turbulent mixing, for mixing efficacy, in a mixing chamber provided in a one-piece flexible and resilient manifold have 'self-sealing' inlet and outlet ports. To enhance mixing, the mixing chamber has an increased cross-sectional area over the combined areas of the component supply passages and the fluid flows are directly opposed to impinge on each other in the mixing chamber. The applicator body and mixing head each have a housing with an ergonomic, streamlined or otherwise smoothly contoured shape and esthetic appearance.

Dispensing head for a tissue sealant applicator and process of use

Multipurpose fluid applicators, particularly suitable for surgical purposes, are disclosed. The applicators are specifically designed for dispensing various combinations of sterile pressurized gas, suction, irrigation and sealant agents, including a mixed liquid sealant agent. Preferred embodiments employ a dual-acting valve selectively to control the flow of gas or suction which valve is capable of simultaneously varying flow from a source and the venting of that flow to atmosphere.

Multipurpose fluid applicator and method, with surgical uses

Multipurpose fluid applicators and applicator tips, particularly suitable for surgical purposes, are disclosed. The applicators and applicator tips are specifically designed for dispensing various combinations of sterile pressurized gas, suction, irrigation and sealant agents, including a mixed liquid sealant agent. Preferred embodiments employ a dual-acting valve selectively to control the flow of gas or suction which valve is capable of simultaneously varying flow from a source and the venting of that flow to atmosphere.

Sealant applicator tip and application method

A method and apparatus for filling a syringe-type applicator having multiple material reservoirs are disclosed. The method and apparatus permits the individual component reservoirs to be simultaneously filled without risk of contamination or unintentional component mixing. The method and apparatus are particularly useful in the preparation and delivery of multiple component tissue sealants such a fibrinogen adhesive compositions.

Growing community of inventors

Fremont, CA, United States of America

Gordon Howard Epstein