Sorbonne Université

Centre National De La Recherche Scientifique

Université Paris Diderot-Paris 7

Centre National De La Recherche Scientifique-cnrs

Universite Paris Cité

Paris Sciences Et Lettres

Paris Sciences Et Lettres-quartier Latin

Gordon Hamilton

David Bensimon

Vincent Croquette

Jean-François Allemand

Jimmy Ouellet

Charles Andre

The invention proposes a device for analyzing nucleic acid molecules (M), comprising: —a bead (), on which one molecule can be anchored at one end, —a surface (), on which the molecule can be anchored at the other end, —an actuator (), adapted to cause the bead to move relative to said surface in one direction, —a sensor (), adapted to measure a distance between the bead and the surface, the device further comprising a well (), having an axis (X-X) extending along the direction of motion of the bead and a bottom () formed by said surface, said well being filled with electrically conductive solution (), and receiving the bead, the sensor being adapted to measure an impedance of the well, depending on a distance between the bead and the surface, to determine, the distance between the bead and the surface.

Device for the analysis of nucleic acid molecules

The invention proposes a device for analyzing nucleic acid molecules (M), comprising: &#x2014;a bead (), on which one molecule can be anchored at one end, &#x2014;a surface (), on which the molecule can be anchored at the other end, &#x2014;an actuator (), adapted to cause the bead to move relative to said surface in one direction, &#x2014;a sensor (), adapted to measure a distance between the bead and the surface, the device further comprising a well (), having an axis (X-X) extending along the direction of motion of the bead and a bottom () formed by said surface, said well being filled with electrically conductive solution (), and receiving the bead, the sensor being adapted to measure an impedance of the well, depending on a distance between the bead and the surface, to determine, the distance between the bead and the surface.

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Paris, France

Gordon Hamilton