Syntex (u.s.a.) Inc.

Other

Syntex LLC

Gordon H Jones

Thomas Gadek

Philip L Felgner

Deborah A Eppstein

Richard B Roman

Michael C Venuti

John M Young

John J Nestor

Brian H Vickery

John J Bruno

John G Moffatt

Robert Alvarez

John J Nestor, Jr

Jurg R Pfister

Pamela M Burton

Abraham White, Deceased

Young, John M

Michael D Edge

N-&lsqb;1, (1-1) -dialkyloxy&rsqb; - and N- &lsqb;1, (1-1) -dialkenyloxy&rsqb;- alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor

This invention relates to compounds of the formula ##STR1## or an optical isomer thereof wherein R.sup.1 and R.sup.2 are the same or different and are an alkyl or alkenyl group of 6 to 24 carbon atoms; R.sup.3, R.sup.4, R.sup.5 are the same or different and are alkyl of 1 to 8 carbon atoms, aryl, aralkyl of 7 to 11 carbon atoms, or when two or three of R.sup.3, R.sup.4, and R.sup.5 are taken together to form quinuclidino, piperidino, pyrrolidino, or morpholino; n is 1 to 8; and X is a pharmaceutically acceptable anion.

N-[.omega., (.omega.-1)-dialkyloxy]- and N-[.omega.,

This invention relates to compounds of the formula ##STR1## or an optical isomer thereof wherein R.sup.1 and R.sup.2 are the same or different and are an alkyl or alkenyl group of 6 to 24 carbon atoms; R.sup.3, R.sup.4 and R.sup.5 are the same or different and are alkyl of 1 to 8 carbon atoms, aryl, aralkyl of 7 to 11 carbon atoms, or when two or three of R.sup.3, R.sup.4, and R.sup.5 are taken together to form quinuclidino, piperidino, pyrrolidino, or morpholino; n is 1 to 8; and X is a pharmaceutically acceptable anion.

N-(1,(1-1)-dialkyloxy)-and N-(1,(1-1)-dialkenyloxy

This invention relates to compounds of the formula ##STR1## or an optical isomer thereof wherein R.sup.1 and R.sup.2 are the same or different and are an alkyl or alkenyl group of 6 to 24 carbon atoms; R.sup.3, R.sup.4 and R.sup.5 are the same or different and are alkyl of 1 to 8 carbon atoms, aryl, aralkyl of 7 to 11 carbon atoms, or when two or three of R.sup.3, R.sup.4, and R.sup.5 are taken together to form quinuclidino, piperidino, pyrrolidino, or morpholino, n is 1 to 8; and X is a pharmaceutically acceptable anion.

N-[1, (1-1)-dialkyloxy]-and N-[1,

This invention relates to compounds of the formula or an optical isomer thereof wherein R.sup.1 and R.sup.2 are the same or different and are an alkyl or alkenyl group of 6 to 24 carbon atoms; R.sup.3, R.sup.4 and R.sup.5 are the same or different and are alkyl of 1 to 8 carbon atoms, aryl, aralkyl of 7 to 11 carbon atoms, or when two or three of R.sup.3, R.sup.4, and R.sup.5 are taken together to form quinuclidino, piperidino, pyrrolidino, or morpholino; n is 1 to 8; and X is a pharmaceutically acceptable anion.

N-[.omega.,(.omega.-1)-dialkyloxy]- and

N-(.omega., (.omega.-1)-dialkyloxy)- and N-(.omega.,

Psoriasis in mammals is relieved by topically administering naphthalenes of the formula: ##STR1## wherein: R.sup.1 is alkoxy, alkylthio, optionally substituted phenoxy or optionally substituted phenylthio;

Naphthalene anti-psoriatic agents

N-.omega.,(.omega.-1)-dialkyloxy)- and

N-(.omega.,(.omega.-1)-dialkyloxy)- and

N[.omega.,(.omega.-1)-dialkyloxy]- and

Naphthalenes of the formula: ##STR1## wherein: m is 1 or 2;

Compounds according to the formula ##STR1## an optical isomer thereof, or a pharmaceutically acceptable acid addition salt thereof wherein:

(2-oxo-1,2,3,5-tetrahydroimidazo[2,1-b]quinoazolinyl)oxyalkylamides,

Psoriasis in mammals is relieved by topically administering naphthalenes of the formula: ##STR1## wherein: R.sup.1 and R.sup.2 are the same and are lower alkoxy, lower alkylthio, optionally substituted phenoxy or optionally substituted phenylthio,

Compounds according to the formula ##STR1## and the pharmaceutically acceptable acid addition salts thereof wherein: n is an integer of 1 to 6;

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Cupertino, CA, United States of America

Gordon H Jones