Genetics Institute, Inc.

Affymetrix, Inc.

Other

Novartis Corporation

Wyeth

Dana-Farber-Cancer Institute Inc.

Children's Medical Center Corporation

Ono Pharmaceutical Co., Ltd.

Whitehead Institute for Biomedical Research

The Wistar Institute

Dana Farber Cancer Inst.

Gordon G Wong

Steven C Clark

David J Lockhart

Rodney M Hewick

Giorgio Trinchieri

Bice Perussia

Michiko Kobayashi

Stanley F Wolf

Pennina Langer-Safer

Mark S Chee

Thomas R Gingeras

Randal J Kaufman

Eugene L Brown

Barrett J Rollins

Charles D Stiles

John M McCoy

Elizabeth A Wang

Alan D D'Andrea

Paul F Schendel

Michael J Agostino

Simon S Jones

Kim Fechtel

Kenneth A Jacobs

Edward R LaVallie

Vikki A Spaulding

David Merberg

John R McCoy

Maurice Treacy

Debra D Donaldson

Lisa Anne Collins-Racie

Hilary Clark

Cheryl Evans

Ian B Pragnell

Gerald J Graham

Hilary F Clark

Robert J Steininger, Ii

Novel means and methods for analyzing hybridization data derived from hybridization assays between a target nucleic acid and differently sequenced polynucleotide probes involve selecting probe sets that define reference sequences for sequence signatures and deriving useful data about the nature of the target nucleic acid molecule based on its hybridization to the probes. The methods are useful for determining whether the target contains a nucleic acid or polypeptide sequence signature, whether the target encodes a member of a gene family, or whether the target is derived from one of any number of genes.

Identification of molecular sequence signatures and methods involving the same

Novel polynucleotides and the proteins encoded thereby are disclosed.

Secreted proteins and polynucleotides encoding them

This application relates to antibodies reactive with a novel homogenous human cytokine, Natural Killer Stimulator Factor (NKSF), having the ability to induce the production of gamma interferon in vitro in human peripheral blood lymphocytes, and a pharmaceutical preparation containing such antibodies.

Natural killer stimulatory factor

This invention provides methods of monitoring the expression levels of a multiplicity of genes. The methods involve hybridizing a nucleic acid sample to a high density array of oligonucleotide probes where the high density array contains oligonucleotide probes complementary to subsequences of target nucleic acids in the nucleic acid sample. In one embodiment, the method involves providing a pool of target nucleic acids comprising RNA transcripts of one or more target genes, or nucleic acids derived from the RNA transcripts, hybridizing said pool of nucleic acids to an array of oligonucleotide probes immobilized on surface, where the array comprising more than 100 different oligonucleotides and each different oligonucleotide is localized in a predetermined region of the surface, the density of the different oligonucleotides is greater than about 60 different oligonucleotides per 1 cm, and the olignucleotide probes are complementary to the RNA transcripts or nucleic acids derived from the RNA transcripts; and quantifying the hybridized nucleic acids in the array.

Expression monitoring by hybridization to high density oligonucleotide arrays

A novel human cytokine, JE factor, and processes for producing it are disclosed. JE may be used in pharmaceutical preparations for stimulating and/or enhancing immune responsiveness and in wound healing and related tissue repair. containing the factor.

DNA encoding human JE cytokine

Map kinase phosphatases and polynucleotides encoding them

Antibodies to natural killer stimulatory factor

This invention provides methods of monitoring the expression levels of a multiplicity of genes. The methods involve hybridizing a nucleic acid sample to a high density array of oligonucleotide probes where the high density array contains oligonucleotide probes complementary to subsequences of target nucleic acids in the nucleic acid sample. In one embodiment, the method involves providing a pool of target nucleic acids comprising RNA transcripts of one or more target genes, or nucleic acids derived from the RNA transcripts, hybridizing said pool of nucleic acids to an array of oligonucleotide probes immobilized on surface, where the array comprising more than 100 different oligonucleotides and each different oligonucleotide is localized in a predetermined region of the surface, the density of the different oligonucleotides is greater than about 60 different oligonucleotides per 1 cm , and the olignucleotide probes are complementary to the RNA transcripts or nucleic acids derived from the RNA transcripts; and quantifying the hybridized nucleic acids in the array.

Methods of identifying nucleic acid probes to quantify the expression of a target nucleic acid

Expression monitoring by hybridization to high density nucleic acid arrays

IL-6 is produced via recombinant DNA techniques. The peptide is useful in the treatment of disorders characterized by deficiencies in hematopoietic cells and in combination with other hematopoietins in cancer therapies.

Production and use of IL-6

Novel means and methods for analyzing hybridization data derived from hybridization assays between a target nucleic acid and differently sequenced polynucleotide probes involve selecting probe sets that define reference sequences for sequence signatures and deriving useful data about the nature of the target nucleic acid molecule based its hybridization to the probes. The methods are useful for determining whether the target contains a nucleic acid or polypeptide or sequence signature, whether the target encodes a member of a gene family, or whether the target is derived from one of any number of genes.

Antibodies reactive with a novel homogeneous human cytokine, Natural Killer Stimulatory Factor, (NKSF), NKSF having the ability to induce the production of gamma interferon in vitro in human peripheral blood lymphocytes, and a pharmaceutical preparation containing such antibodies.

Growing community of inventors

Brookline, MA, United States of America

Gordon G Wong