Commonwealth Scientific and Industrial Research Organisation

Ciba Vision Corporation

Novartis Ag

Aortech Biomaterials Pty Ltd.

Unisearch Limited

E.i. Dupont De Nemours and Company

Navartis Ag

Cardiac Crc Nominees Pty Ltd

Gordon Francis Meijs

Bronwyn Glenice Laycock

Klaus H Schindhelm

Arthur Ho

Dieter Lohmann

Lynn Cook Winterton

Qin Liu

Peter Chabrecek

Judy Smith Riffle

Angelika Maria Domschke

Paul Clement Nicolson

Richard Carlton Baron

Wilson Leonard Terry, Jr

Deborah Sweeney

John Court

Jens Hopken

Jurgen Vogt

Eric Papaspiliotopoulos

Ezio Rizzardo

Pathiraja Arachchillage Gunatillake

Hassan Chaouk

Hans Jorg Griesser

San Hoa Thang

Timothy Charles Hughes

Hans Jorge Griesser

Anthony Brian Clayton

Graham M Johnson

John Gerard Steele

Raju Adhikari

Peter Agapitos Kambouris

Edith Cheong

Madeleine Clare Griffiths

Simon John McCarthy

Simon J McCarthy

Jürgen Vogt

Hans Jörg Griesser

John Stuart Wilkie

Arthur Brandwood

Eric Papspiliotopoulos

Jens Höpken

Graham Johnson

Klaus Schindhelm

A method for making a silicone hydrogel contact lens is provided. In one embodiment, a prepolymer mixture is polymerized in a lens mold in an atmosphere having less than about 10000 ppm oxygen to form a silicone hydrogel contact lens suitable for extended wear as characterized by producing less than 10% corneal swelling after a period of continuous wear of 7 days including normal sleep periods. In one embodiment, the prepolymer mixture comprises at least one oxyperm material containing hydrophilic groups, wherein the at least one oxyperm material is a siloxane-containing macromer or monomer, at least one ionperm material, and a cross-linking agent. In certain embodiments, the polymerization of the prepolymer mixture may be carried out in an atmosphere having less than about 1000 ppm oxygen.

Extended wear ophthalmic lens

A method for making a silicone hydrogel contact lens is provided. In one embodiment, a prepolymer mixture is polymerized in a lens mold in an atmosphere having less than about 10000 ppm oxygen to form a silicone hydrogel contact lens suitable for extended wear as characterized by producing less than 10% corneal swelling after a period of continuous wear of 7 days including normal sleep periods. In one embodiment, the prepolymer mixture comprises at least one oxyperm material containing hydrophilic groups, wherein the at least one oxyperm material is a siloxane-containing macromer or monomer, at least one ionoperm material, and a cross-linking agent. In certain embodiments, the polymerization of the prepolymer mixture may be carried out in an atmosphere having less than about 1000 ppm oxygen.

An ophthalmic lens suited for extended-wear periods of at least one day on the eye without a clinically significant amount of corneal swelling and without substantial wearer discomfort. In one embodiment, an ophthalmic lens is a copolymerization product of at least one oxyperm, at least one ionoperm, and a crosslinker. In one embodiment, a lens has a tensile modulus of less than about 3.0 MPa, yet in another embodiment, the tensile modulus is between about 0.5 to about 1.5 MPa.

A method of preparing intraocular lenses in situ is disclosed. The method involves the injection of an unsaturated macromonomer of Formula I:  The macromonomer is then polymerized to give a polymer suitable for use in an intraocular lens.

Biomedical compositions

An ophthalmic lens suited for extended-wear periods of at least one day on the eye without a clinically significant amount of corneal swelling and without substantial wearer discomfort. The lens has a balance of oxygen permeability and ion or water permeability, with the ion or water permeability being sufficient to provide good on-eye movement, such that a good tear exchange occurs between the lens and the eye. A preferred lens is a copolymerization product of a oxyperm macromer and an ionoperm monomer. The invention encompasses extended wear contact lenses, which include a core having oxygen transmission and ion transmission pathways extending from the inner surface to the outer surface.

A method of preparing intraocular lenses in situ is disclosed. The method involves the injection of an unsaturated macromonomer of the formula The macromonomer is then polymerized to give a polymer having an E modulus in the range 0.5-5 kPa.

Biomedical composition

A hydrophilic ethylenically unsaturated macromonomer is disclosed that is prepared by the addition polymerization of addition polymerizable monomers that include monomers that have hydroxyl or amino functional groups, some of which may be subsequently reacted to provide (meth)acryl ethylenic unsaturation. The macromonomers may be used to form intraocular lenses in situ by polymerization of the macromonomers, and thus treat presbyopia.

Hydrophilic biomedical compositions

A silicon-based polycarbonate of formula (I):wherein R, R, R, R, R, R, Rand Rare the same or different and selected from hydrogen or an optionally substituted straight chain, branched or cyclic, saturated or unsaturated hydrocarbon radical; Ris a divalent linking group or an optionally substituted straight chain, branched or cyclic, saturated or unsaturated by hydrocarbon radical; A is an endcapping group; n, y and z are integers of 0 or more; and x is an integer of 0 or more.

Silicon-based polycarbonates

A shape memory polyurethane or polyurethane-urea polymer including a reaction product of: (A) (a) silicon-based macrodiol, silicon-based macrodiamine and/or polyether of the formula (I): A&#x2014;[(CH)&#x2014;O]&#x2014;(CH)&#x2014;A', wherein A and A are endcapping groups; m is an integer of 6 or more; and n is an integer of 1 or greater; (b) a diisocyanate; and (c) a chain extender; or (B) (b) a diisocyanate: and (c) a chain extender, said polymer having a glass transition temperature which enables the polymer to be formed into a first shape at a temperature higher than the glass transition temperature and maintained in said first shape when the polymer is cooled to a temperature lower than the glass transition temperature, said polymer then being capable of resuming its original shape on heating to a temperature higher than the glass transition temperature. The present invention also relates to a shape memory composition which includes a blend of two or more of the shape memory polyurethane or polyurethane-urea polymers defined above or at least one shape memory polyurethane or polyurethane-urea polymer defined above in combination with another material. The present invention further relates to processes for preparing materials having improved mechanical properties, clarity, processability, biostability and/or degradation resistance and devices or articles containing the shape memory polyurethane or polyurethane-urea polymer and/or composition defined above.

Shape memory polyurethane or polyurethane-urea polymers

A hydrophilic ethylenically unsaturated macromonomer is disclosed that is prepared by the addition polymerization of addition polymerizable monomers that include monomers that have hydroxyl or amino functional groups, some of which may be subsequently reacted to provide (meth)acryl ethylenic unsaturation. The macromonomers may be used to form intraocular lenses in situ by polymerization of the macromonomers.

Hydrophilic biomedical composition

Hydratable siloxane comprising porous polymers

The present invention relates to a material having improved mechanical properties, clarity, processability and/or degradation resistance comprising a polyurethane elastomeric composition which includes a soft segment derived from at least one polysiloxane macrodiol and at least one polyether and/or polycarbonate macrodiol. This material can function as a degradation-resistant material or biomaterial and is particularly useful in the manufacture of medical devices, articles or implants which contact living tissue or bodily fluids. The present invention also provides a polyurethane elastomeric composition which includes a soft segment derived from at least one polysiloxane and at least one polyether and/or polycarbonate macrodiol and processes for its preparation.

Polysiloxane-containing polyurethane elastomeric compositions

Growing community of inventors

Murrumbeena, Australia

Gordon Francis Meijs