Intel Corporation

Lux Bio Group Inc.

Gordon D Holt

Brandon Barnett

Hernan Adolfo Castro

Wei W Wang

Valery M Dubin

Florian Gstrein

Handong Li

Narayan Sundararajan

Ghadeer Antanius

Xiao-Feng Qi

Narayanan Sundararajan

Richard Wykoff

Sorin Davidovici

A device having a nanochannel within a support material, wherein the nanochannel comprises one or more sidewall electrodes; a nanomembrane inside the nanochannel, wherein the nanomembrane encircles a nanopore, has a hydrophobic surface, and is in direct contact with at least a portion of one sidewall electrode of the nanochannel; a lipid bilayer on the hydrophobic surface, the lipid bilayer spanning the nanopore and having a protein nanopore disposed into the lipid bilayer; wherein a size of the nanopore is tuned such that the lipid bilayer spanning the nanopore only accommodates a single protein nanopore.

Apparatus and method for molecular separation, purification, and sensing

Described are devices and methods for forming one or more nanomembranes including electroactive nanomembranes within a nanowell or nanotube, or combinations thereof, in a support material. Nanopores/nanochannels can be formed by the electroactive nanomembrane within corresponding nanowells. The electroactive nanomembrane is capable of controllably altering a dimensionality, a composition, and/or a variety of properties in response to electrical stimuli. Various embodiments also include devices/systems and methods for using the nanomembrane-containing devices for molecular separation, purification, and sensing.

Described herein is a device including a nanotube disposed within a support material. The nanotube has one or more sidewall electrodes, two nanomembranes, and an enzyme. One of the nanomembrane is in direct contact with at least a portion of one sidewall electrode. The other nanomembrane form a nanochannel, nanopore, or a combination thereof, and can alter one or more of a molecular composition, a dimension, or a property thereof in response to electrical stimuli.

Described are devices and methods for forming one or more nanomembranes including electroactive nanomembranes within a nanowell or nanotube, or combinations thereof, in a support material. Nanopores/nanochannels can be formed by the electroactive nanomembrane within corresponding nanowells. The electroactive nanomembrane is capable of controllably altering a dimension, a composition, and/or a variety of properties in response to electrical stimuli. Various embodiments also include devices/systems and methods for using the nanomembrane-containing devices for molecular separation, purification, sensing, etc.

A wafer having a plurality of dies (also called array chips) on the wafer, the die having an electrode to generate a deprotecting reagent, a working electrode to electrochemically synthesize a material, a confinement electrode adjacent to the working electrode to confine reactive reagents, and a die pad, wherein die pads of the plurality of dies are interconnected on the wafer to electrochemically synthesize the material in parallel on a plurality of working electrodes is disclosed. Also, a method for wafer-scale manufacturing of a plurality of dies and a method for electrochemically synthesizing a material in parallel on a plurality of dies on a wafer are disclosed.

Method and apparatus to fabricate polymer arrays on patterned wafers using electrochemical synthesis

Described are devices and methods for detecting the match quality and concentration of analytes binding to an electrode surface. The devices utilize a clock to measure capacitance change as a function of time and a temperature controller to measure the capacitance change as a function of temperature.

Method and apparatus for match quality analysis of analyte binding

Described are devices and methods for detecting binding on an electrode surface. In addition, devices and methods for electrochemically synthesizing polymers and devices and methods for synthesizing and detecting binding to the polymer on a common integrated device surface are described.

Method and apparatus for combined electrochemical synthesis and detection of analytes

Described are quality control methods and devices for the reproducible manufacturing and integrity monitoring of polymers on electrochemical synthesis and detection chips. The devices and methods allow for simultaneous manufacturing and synthesis of polymers.

Growing community of inventors

Santa Clara, CA, United States of America

Gordon D Holt