Mcgill University

University of California

The Royal Institution for the Advancement of Learning / Mcgill University

Gemin X Biotechnologies Inc.

Gordon C Shore

Mai Nguyen

Philip E Branton

Roy A Johnson

Florence W H Ng

Madiraju S R Murthy

Nancy A E Steenaart

James H Frederich

Patrick Harran

Richard C Marcelius

Jose G Teodoro

Ing Swie Goping

Josee N Lavoie

Provided herein are Mcl-1 antagonist compositions and methods of treating cancer using the compositions described herein.

MCL-1 antagonists

Provided herein are Mcl-1 antagonist compositions and methods of treating g the compositions described herein.

Mcl-1 antagonists

The invention features E4orf4-encoding nucleic acids, pharmaceutical compositions and expression vectors containing the same, and methods for their use. E4orf4-encoding nucleic acids include (i) nucleic acids capable of hybridizing at high stringency to the complement of the nucleic acid encoding Ad2E4orf4, and (ii) nucleic acids having 50% or greater nucleotide sequence identity to the nucleotide sequence of Ad2E4orf4, so long as the nucleic acids encode a polypeptide capable of inducing apoptosis.

Adenovirus E4 proteins for inducing cell death

The invention provides a novel apoptosis protein: p28 Bap31. Also provided are p28 Bap31 polypeptide fragments, p28 Bap31 antisense nucleic acid molecules, anti-p28 Bap31 antibodies, and methods for modulating apoptosis and for detecting compounds which modulate apoptosis.

Methods and reagents for modulating apoptosis

The present invention relates to novel Pyrrole-Type compounds, compositions comprising Pyrrole-Type compounds, and methods useful for treating or preventing cancer or a neoplastic disorder comprising administering a composition comprising a Pyrrole-Type compound. The compounds, compositions, and methods of the invention are also useful for inhibiting the growth of a cancer cell or neoplastic cell. The present invention also relates to novel Pyrrole-Type compounds, compositions, and methods useful for treating or preventing a viral infection. The compounds, compositions, and methods of the invention are also useful for inhibiting the replication and/or infectivity of a virus.

Pyrrole-type compounds, compositions, and methods for treating cancer or viral diseases

The invention features p28 Bap31 polypeptides and nucleic acids. The invention also features methods for modulating apoptosis using these polypeptides and nucleic acids, and methods for identifying apoptosis-modulating compounds.

Growing community of inventors

CA

Gordon C Shore