American Cyanamid Company

Gordon C Lawrence

David Noble

Michael J Dawson

Richard A Fletton

Michael V Ramsay

Derek R Sutherland

Edward P Tiley

Stephen J Lane

Richard Bell

Oswy Z Pereira

Martin Todd

Mark A Haxell

A process for the production of a compound of formula (I) ##STR1## which comprises cultivating a microorganism of the genus Streptomyces capable of producing the compound of formula (I) in the presence of one or more fatty acids and/or salts, esters and amides of these acids, whereby the compound of formula (I) is produced, and if desired isolating the said compound. The fatty acid increases the yield of the formula (I) compound and is preferably isobutyric or valeric acid.

Process for the production of macrolide compounds

Compounds of formula (1) ##STR1## wherein R represents a sugar residue or an acylated derivative thereof;

Macrolide compounds

Compounds of formula (1) ##STR1## and their salts, wherein R.sup.1 is a methyl, ethyl or isopropyl group each substituted by a hydroxyl group or R.sup.1 is a group --(CH.sub.2).sub.n R7 or a group --CH(CH.sub.3)R.sup.7 (where n is zero or 1 and R.sup.7 l is CHO or CO.sub.2 H);

Compounds of formula (1) ##STR1## and salts thereof, wherein R.sup.1 represents a methyl, ethyl or isopropyl group;

Growing community of inventors

Burnham, United Kingdom

Gordon C Lawrence