Aratana Therapeutics, Inc.

Argenta Manufacturing Limited

Elanco Animal Health Gmbh

Gopinath Devaraj

Tamara Newbold

Lesley Rausch-Derra

Akemi Shiraishi

David Anthony Gill

Douglas Robert Cleverly

Keryn Davies

Priyanka Agarwal

Su Win

Bill Zollers

Linda Rhodes

Ernst Heinen

The present disclosure provides a method for treating pain or inflammation in a non-human animal in need thereof. The method comprises administering to a non-human animal a pharmaceutical composition comprising a therapeutically effective amount of grapiprant. Also provided herein are pharmaceutical compositions for treating pain or inflammation in a non-human animal in need thereof. The pharmaceutical compositions comprise a therapeutically effective amount of grapiprant and an excipient, including flavorants.

Compositions of grapiprant and methods for using the same

The invention provides for a method of treating inappetance-induced weight loss in one or more companion animals or livestock. The method provides for administering a therapeutically effective amount of a capromorelin-containing composition to the companion animal or livestock. Optionally, one or more flavoring agents or flavor-masking agents can be added to the capromorelin-containing composition to enhance or mask the flavoring of the composition for the companion animal or livestock.

Compositions and methods of use of an inappetance-controlling compound

The present invention relates to a chewable formulation for delivering a nutritional or pharmaceutically active agent to an animal target. The chewable formulation comprises a nutritional ingredient or an effective amount of a pharmaceutically active agent, and a plasticizer. The chewable formulation is formed by extrusion and the formulation contains substantially no unbound water, nor is any water added in the manufacturing process. The present invention also relates to a method of manufacturing a shelf stable chewable formulation which comprises mixing the nutritional or pharmaceutically active agent with a fat, lipid or fat and lipid to obtain a first composition, adding one or more plasticizers to the first mixture to obtain a second composition, extruding the second composition at a temperature sufficient to melt the fat and lipid, and allowing the extruded second composition to cool to room temperature thereby providing the chewable formulation.

Extruded chewable formulation comprising bound water

Method of making an anhydrous, fat soluble, chewable drug delivery formulation

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Auckland, New Zealand

Gopinath Devaraj