Beth Israel Deaconess Medical Center, Inc.

Gopal Varma

David C Alsop

A magnetic resonance imaging (MRI) system is provided that is controlled by a computer. The computer is programmed to control a plurality of gradient coils and radio frequency (RF) system of the MRI system to perform at least one pulse sequence that includes applying RF energy at least at two frequencies to manipulate exchangeable magnetization from protons in a subject. The computer is also programmed to control the plurality of gradient coils and RF system to acquire imaging data including magnetization transfer information from the exchangeable magnetization from protons in the subject in response to the pulse sequence. The computer is further programmed to, using frequency information associated with the imaging data, generate a report pertaining to inhomogeneous magnetization transfer occurring in the subject in response to the pulse sequence.

System and method for inhomogeneous magnetization transfer magnetic resonance imaging

A system and methods for improved homogeneous and inhomegeneous magnetic transfer imaging are provided. In some aspects, a plurality of gradient coils and an RF system of a magnetic resonance imaging ('MRI') system are controlled, using a computer, to perform, at least one pulse sequence that includes a preparation module followed by an imaging module, wherein the preparation module comprises a plurality of radio frequency ('RF') saturation pulses applied according to a concentrated pulse cycle to manipulate exchangeable magnetization from protons in the subject, and the imaging module is configured to acquire image data. The computer is also configured to analyze the image data acquired to generate frequency information indicative of the exchangeable magnetization from protons in the subject, and generate a report, using the frequency information, pertaining to inhomogeneous or homogeneous magnetization transfer occurring in the subject.

System and method for improved homogeneous and inhomogeneous magnetization transfer magnetic resonance imaging

A system and method for producing a report about a subject from data collected from the subject using a magnetic resonance imaging (MRI] system. The method includes directing the MRI system to perform a pulse sequence to manipulate exchangeable magnetization in the subject and acquiring, with the MRI system, imaging data from the subject in response to the pulse sequence. The method also includes analyzing the effects of the frequencies of applied RF energy on the imaging data to identify inhomogeneous lines formed by a summation of multiple sublines centered at multiple different frequencies. The method further includes generating a report pertaining to inhomogeneous magnetization transfer occurring in the subject in response to the pulse sequence.

System and method for magnetic resonance imaging using exchange time reflective of motion restriction or spin diffusion of protons bound to macromolecules

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Gopal Varma