Columbia University

Yes, Inc.

Gopal Singh

Matthew D Bacchetta

James M Sinclair

Harold Coons

Linda Eastwood

Gordana Vunjak-Novakovic

John O'Neill

Donald O Freytes

Scott A Kanner

Joshua Sonett

The present invention provides hemostatic compositions comprising components of the flowers of pharmaceutical chamomile (), the leaves of dioecious nettle (), kaolin, chitosan, fibrinogen and thrombin. Further inclusion of a biocompatible polymeric base, particularly an alignate, generates a composition with superior and broad spectrum hemostatic capabilities, including the ability to arrest arterial hemorrhage. The invention further provides methods of using the inventive compositions in to reduce or stop bleeding, as well as a variety of apparatuses useful in hemostatic contexts that incorporate the inventive compositions. In one particular embodiment, the invention provides hemostatic dressings in which a polymeric layer incorporating chamomile, nettle, kaolin, chitosan, fibrinogen and thrombin components is applied to a textile or fabric material, for example a non-woven viscose.

Hemostatic compositions and dressings for bleeding

The vasculature of a donor lung is perfused with a lung preserving fluid to preserve its structure. At the same time, a decellularization fluid is perfused through the airways, which strips away donor cells. The decellularized region is then seeded with pulmonary cells of the transplant recipient, which regenerate the lung. The pulmonary cells may be derived from stem cells, and the decellularization can be targeted to reduce the quantity of cells required.

Functional recovery of human lungs for transplantation

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New York, NY, United States of America

Gopal Singh