Ludwig Institute for Cancer Research Limited

Oxford University Innovation Limited

The University of Birmingham

Gopal Reddy

Gerd J Ritter

Richard R Schmidt

Gurdyal S Besra

Vincenzo Cerundolo

Mariolina Salio

Jonathan Silk

Rengarajan Balamurugan

Analogs of alpha galactosylceramide and uses thereof

There are disclosed compound of formula I, in which Rrepresents a hydrophobic moiety adapted to occupy the C' channel of human CDId, Rrepresents a hydrophobic moiety adapted to occupy the A&#x2032; channel of human CDId, such that Rfills at least at least 30% of the occupied volume of the C&#x2032; channel compared to the volume occupied by the terminal nCHof the sphingosine chain of &#x3b1;-galactosylceramide when bound to human CDId and Rfills at least 30% of the occupied volume of the A&#x2032; channel compared to the volume occupied by the terminal nCHof the acyl chain of &#x3b1;-galactosylceramide when bound to human CDId Rrepresents hydrogen or OH, Rand Reach represent hydrogen and in addition, when Rrepresents hydrogen, Rand Rtogether may form a single bond, X represents or &#x2014;CHA(CHOH)Y or &#x2014;P(=0)(0)0CH(CH0H)Y, in which Y represents CHBB, n represents an integer from 1 to 4, m represents 0 or 1, A &#xe5;represents hydrogen, one of Band Brepresents H, OH or phenyl, and the other represents hydrogen or one of Band Brepresents hydroxyl and the other represents phenyl, in addition, when n represents 4, then A together with one of Band Btogether forms a single bond and the other of Band Brepresents H, OH or OSOH and pharmaceutically acceptable salts thereof; the compounds of formula I are indicted for use in the treatment of a virus, microbial infection, parasite, an autoimmune disease, cancer, allergy or asthma. 

Analogs of alpha galactosyceramide and uses thereof

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Stony Brook, NY, United States of America

Gopal Reddy