Smithkline Beecham Corporation

Gopadi M Venkatesh

Nageswara R Palepu

Sarma Duddu

Manga R Gudipati

John Michael Jushchyshyn

Miriam K Franchini

This invention relates to (E)-&agr;-&lsqb;2-n-butyl-1-&lsqb;(4-carboxyphenyl)methyl&rsqb;-1H-imidazol-5-yl&rsqb;methylene-2-thiophenepropionic acid arginyl charge-neutralization-complex, a process for its production, compositions containing the compound and methods of using the compound to block angiotensin II receptors and to treat hypertension, congestive heart failure and renal failure.

Eprosartan arginyl charge-neutralization-complex and a process for its preparation and formulation

This invention relates to high drug load granulation of (E)-&agr;-&lsqb;2-n-butyl-1-&lsqb;(4-carboxyphenyl)methyl&rsqb;-1H-imidazol-5-yl&rsqb;methylene-2-thiophenepropionic acid in the anhydrous form, a process for its production, compositions containing the compound and methods of using the compound to block angiotensin II receptors and to treat hypertension, congestive heart failure and renal failure.

High drug load immediate and modified release oral dosage formulations and processes for their manufacture

This invention relates to bioenhanced formulations comprising eprosartan or eprosartan mesylate in the amorphous form, a process for its production, compositions containing the compound and methods of using the compound to block angiotensin II receptors and to treat hypertension, congestive heart failure and renal failure.

Bioenhanced formulations comprising eprosartan in oral solid dosage form

This invention relates to carvedilol methanesulfonate, compositions containing this compound and methods of using carvedilol methanesulfonate to treat hypertension, congestive heart failure and angina.

Carvedilol methanesulfonate

This invention relates to a method for the manufacture of Bite-dispersion tablets which disperse easily and quickly in the oral cavity, after a gentle bite, without the aid of water, and if necessary includes masking the bitter taste of medicaments. The process comprises preparing a dry granulation of one or more of medicaments blended with suitable excipients, flavors and a combination of a waxy material and phospholipid (BMI-60) or an intense sweetener derived from fruit flavonoids (Neohesperidine) for taste-masking and compressing into tablets which can be packaged in bottles or blisters using conventional equipment.

Process for manufacturing bite-dispersion tablets

The invention relates to (E)-&agr;-&lsqb;2-n-butyl-1-&lsqb;(4-carboxyphenyl)methyl&rsqb;-1-H-imidazol-5-yl&rsqb;methylene-2-thiopheneproprionic acid monomethanesulfonate dihydrate, a process for its production, compositions containing the compound and methods of using the compound to block angiotensin II receptors and to treat hypertension, congestive heart failure and renal failure.

Eprosartan dihydate and a process for its production and formulation

A process for preparing controlled release solid dosage forms of lithium carbonate by using a dissolution rate stabilizer and a hydrophobic waxy material.

Controlled release solid dosage forms of lithium carbonate

This invention relates to (E)-&agr;-&lsqb;2-n-butyl-1-&lsqb;(4-carboxyphenyl)methyl&rsqb;-1) H-imidazol-5-yl&rsqb;methylene-2-thiophenepropionic acid monomethanfesulfonate monohydrate, compositions containing the compound and methods of using the compound to block angiotensin II receptors and to treat hypertension, congestive heart failure and renal failure.

Eprosartan monohydrate

Invented are methods of transporting quantities of potassium clavulanate. Also invented are methods of forming a uniform continuous waxy barrier around medicament particles.

Pharmaceutical thermal infusion process

Invented are controlled release formulations of medicaments for oral administration comprising a hydrophobic waxy material and prepared by thermal infusion.

Growing community of inventors

Blue Brook, OH, United States of America

Gopadi M Venkatesh