Other

Samsung Electronics Co., Ltd.

Korea Research Institute of Bioscience and Biotechnology

Goo Taeg Oh

Kyung Seop Ahn

Sei Ryang Oh

Hyeong Kyu Lee

Jung Hee Kim

Soon Ja Choi

Jung Joo Hong

Han-Woong Lee

Seong Kyu Park

Woo Namkung

Jaekyoon Shin

This invention includes a composition ofand tilianin obtained by separation-purification for anti-inflammation and anti-atherosclerosis, and more particularly, an extract ofand tilianin obtained therefrom by separation-purification which are effective in preventing and treating not only inflammatory diseases but also atherosclerosis related to inflammatory responses and disease in the circulatory system caused by atherosclerosis because they are excellent in inhibiting the activity of complement systems as a factor of inflammatory responses, the expression of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecular-1 (VCAM-1), and the production of nitric oxide (NO). They can also significantly reduce the development of atherosclerosis due to the inflammatory response.

[object Object]

The application discloses a role of p62 in aging-related disease, such as development of obesity, type 2 diabetes mellitus, non-alcoholic fatty liver, various tumors, increased male mortality, intracellular inclusion named sequestosome, and redox regulation. In particular the application discloses a method of detecting the formation of inclusion bodies in neurodegenerative diseases. The invention further relates to a method of screening for therapeutic agents that disperse the inclusions. Further, transgenic mice containing a mutation in the p62 gene and having a functionally disrupted p62 gene locus are also disclosed.

Role of p62 in aging-related disease

Growing community of inventors

Daejeon, South Korea

Goo Taeg Oh