Asahi Kasei Pharma Corporation

Goichi Honda

Akio Matsuda

Shuji Muramatsu

Yukiko Nagano

Provided are proteins having NF-&#x3ba;B activity, which are used for diagnosing, treating or preventing diseases associated with the excessive activation or inhibition of NF-&#x3ba;B. Using plasmid pNF &#x3ba;B-Luc, cDNA encoding a protein capable of activating NF-&#x3ba;B has been cloned from a cDNA library constructed from human lung fibroblasts, and the DNA sequence and the deduced amino acid sequence determined. The protein, the DNA encoding the protein, a recombinant vector containing the DNA, and a transformant containing the recombinant vector are useful for screening a substance inhibiting or promoting NF-&#x3ba;B activation.

NF-&#x3ba;B activating gene

Provided are proteins having NF-&#x3ba;B activity, which are used for diagnosing, treating or preventing diseases associated with the excessive activation or inhibition of NF-&#x3ba;B. Using plasmid pNF&#x3ba;B-Luc, cDNA encoding a protein capable of activating NF-&#x3ba;B has been cloned from a cDNA library constructed from human lung fibroblasts, and the DNA sequence and the deduced amino acid sequence determined. The protein, the DNA encoding the protein, a recombinant vector containing the DNA, and a transformant containing the recombinant vector are useful for screening a substance inhibiting or promoting NF-&#x3ba;B activation.

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Fuji, Japan

Goichi Honda