Tanabe Seiyaku Company, Limited

Goichi Hirata

Masayoshi Samejima

Yoshiyuki Koida

Akira Kida

Takashi Ishibashi

Yoshinori Kobayashi

A process for preparing free-flowing microcapsules by taking advantage of the phase-separation of ethylcellulose in cyclohexane is disclosed. In this process, a hydrocarbon compound which is soluble in cyclohexane and have a molecular weight of 150 to 3,000 and a solubility parameter (.delta., at 25.degree. C.) of 7 to 10 (cal/cm.sup.3).sup.1/2 is used as the phase-separation-inducing agent.

Process for preparing free-flowing ethylcellulose microcapsules

Pharmaceutically active compound-containing microcapsules the coating walls of which consist essentially of ethylcellulose and a water-insoluble, acid-soluble polymer material are disclosed. A method of preparing said microcapsules is also disclosed.

Process for preparing ethylcellulose microcapsules

Ethylcellulose microcapsules, wherein a polymer material which shows at least 1.2 times increase in weight by immersing it in water at 37.degree. C. is incorporated into the ethylcellulose coating walls and/or the core material thereof, are disclosed. Said ethylcellulose microcapsules show rapid release of the core material in digestive organs such as stomach.

Microcapsules and method of preparing same

Microcapsules are prepared by conducting the phase-separation of a coating polymer material in the presence of ethylcellulose. Ethylcellulose present in the phase separation system minimizes the coagulation of the coating polymer material.

Method of preparing microcapsules

A process for preparing ethylcellulose microcapsules by flocculation of the ethylcellulose is disclosed. In this process, the flocculation of the ethylcellulose is carried out in the presence of an organosilicon polymer or in the presence of said organosilicon polymer and a surfactant.

A process for preparing ethylcellulose microcapsules of a pharmaceutically active compound by phase separation-coacervation of the ethylcellulose is disclosed. In this process, phospholipids are used as a phase-separation-inducing agent.

Process for preparing pharmaceutically active compound-containing

A process for the preparation of pharmaceutical substance-containing microcapsules by liquid-liquid phase separation is disclosed. In this process, ethyl cellulose having an ethoxy content of about 48 to about 49.5% by weight is used as a wall-forming agent and polyisobutylene is used as a phase separation inducing agent, and both or either one of the ethyl cellulose and polyisobutylene are used in the form of a mixture of two kinds differing in the average molecular weight.

Growing community of inventors

Yawata, Japan

Goichi Hirata