Isf S.p.a.

Craf Sud

Goffredo Bolis

Mario Pinza

Roberto P Giani

Giampietro Broccali

Giorgio Pifferi

Piero Bellani

There is described a new class of ketohydroxyimino derivatives of cephalosporins of the formula ##STR1## wherein: R is an alkyl radical having from 2 to 4 carbon atoms, a phenyl, or a 5-membered heterocyclic radical which may be substituted, containing nitrogen, oxygen and/or sulphur;

Ketoiminocephalosporin derivatives

Formyl derivatives of hydrazinopenicillins of the formula ##STR1## wherein R is thienyl or phenyl, R' is hydrogen, formyl or alkyl containing from 1 to 3 carbon atoms and R' is hydrogen or formyl, provided that at least one of R' and R' is a formyl group, the carbon atom with the asterisk indicating a center of asymmetry of the molecule, and pharmaceutically acceptable salts and esters thereof, as mixture or as separated epimers. These compounds have antibacterial activity against Gram-negative and Gram-positive bacteria and are prepared by a process wherein the corresponding hydrazinopenicillin is reacted under anhydrous conditions with acetoformic anhydride to give the desired compounds.

Formyl derivatives of hydrazinopenicillins

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Bergamo, Italy

Goffredo Bolis