Nxstage Medical, Inc.

Goetz Friederichs

Jeffrey H Burbank

Dennis M Treu

James M Brugger

Scott W Newell

William J Schnell

William K Weigel

Christopher S McDowell

Brian Green

Orlando Soto

Joseph E Turk, Jr

Mark T Wyeth

Jerome James

David Desouza

Daniel Joseph Rubery, Jr

Garrett Casey

Yuriy N Tatashin

Jeffery B Hover

Keith David J Wheeler

Amanda Wozniak

Joseph Rausa

Christopher S Mcdowell

Gregory Yantz

Robert Paul McCarty

Ciro A De La Vega

Joseph Turk

Keith J Wheeler

Jefferey B Hover, Sr

Kevin Hughes

Daniel J Rubery

Brian C Green

Garrett D Casey

A system for preparing a medicament for use by a medicament user includes a proportioning machine with a controller and pumping and clamping actuators to engage a fluid circuit having pumping and clamping portions that engage with respective actuators of the proportioning machine. The fluid circuit includes a mixing container that is initially empty and later filled with a concentrated medicament from a concentrate container. The proportioning machine is configured to receive purified water and to mix it with the concentrated medicament to produce a medicament and to output the medicament to a medicament consumer in such a way that to the medicament consumer the medicament appears to be provided from a bag of medicament.

Medicament preparation devices, methods, and systems

A method of automatically ensuring against chloramine contamination in purified product water includes supplying input water to the system and purifying the water to generate the purified product water. The purifying includes removing chlorine and chloramine contamination from the water using a carbon filter and supplying chlorine-depleted water to a deionization filter, and deionizing the chlorine-depleted water using said deionization filter. The product water is supplied to a sensor for continuous monitoring of the resistivity of the purified product water by the first sensor, and an alarm is generated indicating possible chloramine breakthrough when the resistivity of the product water falls below a predetermined resistivity level, which is selected to provide a reserve filter capacity before breakthrough would occur. The carbon filter is replaced at least responsively to the alarm to ensure excess capacity of said carbon filter sufficient to prevent chloramine breakthrough in said product water.

Water treatment systems, devices, and methods for fluid preparation

A fluid treatment plant has a filter module including at least a first filter and a second filter connected in series and connectable to a supply of fluid. A pump is fluidly connected to the filter module and a controller with a fluid quality sensor is connected to detect a quality of the fluid between the first filter and the second filter. A filter module detector is connected to the controller configured to uniquely detect a filter module connected to the pump, and the controller is controls the pump responsively to a signal from the fluid quality sensor and the module detector. The controller is configured to continue pumping based on output of the quality sensor and/or based on output from the filter module detector.

Filtration system for preparation of fluids for medical applications

A medicament preparation system includes a water purification module and a medicament proportioning module that is interoperable with a replaceable fluid circuit. The fluid circuit includes a purified water inlet, a product medicament outlet, and a plurality of pumping tube segments. At least a first concentrate container is connected by at least a portion of the fluid circuit to the product medicament output and a first concentration measurement sensor station is positioned in a flow path. A controller is programmed to calculate iteratively a concentration of a first concentrate from the first concentrate container and the purified water from a signal generated by the first concentration measurement sensor station and to regulate one or both of a first pumping actuator engaged with the first pumping tube segment and a second pumping actuator engaged with the second pumping tube segment, responsively to the concentration of the first concentrate and water.

Medicament preparation and treatment devices, methods, and systems

The disclosed subject matter relates to extracorporeal blood processing or other processing of fluids. Volumetric fluid balance, a required element of many such processes, may be achieved with multiple pumps or other proportioning or balancing devices which are to some extent independent of each other. This need may arise in treatments that involve multiple fluids. Safe and secure mechanisms to ensure fluid balance in such systems are described.

Flow balancing devices, methods, and systems

A system for mixing a batch of medicament has a pump actuator, control valve actuators, a source of concentrate, and a purified water source, all connected by a fluid circuit. A controller controls various control valves to open fluid channels from the source of concentrate and from the purified water source to connect a junction of the fluid circuit to the concentrate container and the purified water source. The controller also controls the pump actuator and a water pump to flow water and concentrate through the junction into a mixing container, such that the mixture of the concentrate and the water requires additional dilution to form a ready-to-use medicament. The controller samples the mixture and calculate an additional quantity of water to add based on the sampling.

A fluid purification system has cells whose purifying capability can be regenerated. Some of the cells are arranged in series to reach a high level of purification. An automatic valve network is controlled to cycle the cells in a way that levels the loads on each, thereby maximizing the service interval for replacing expired cells, enabling all of the cells to be replaced at the same time after having each contributing approximately equally to the purification load, and operated such that at any one time, at least one cell is regenerated so as to enable continuous up-time.

Fluid purification methods, devices, and systems

A medicament preparation system includes a disposable cartridge with a flow path. Various sensors may be placed on the cartridge to measure qualities of the fluid flowing through the flow path. The sensors are placed in precise locations using various approaches that make manufacturing of the cartridge efficient and repeatable. A drain line that is susceptible to fouling may be preattached and various approaches are used to remove or reduce the fouling. An elastomeric contact can also be present in the medical preparation system and used in a conductivity measurement subsystem.

Fluid management and measurement systems, devices, and methods

A conductivity measurement device includes first and second conductivity measurement flow channels positioned in a fluid circuit and fluidly linked for fluid flow between the first and second conductivity measurement flow channels. A controller having a current source connected to the first and second conductivity channels applies alternating voltages at frequencies that are different, each being respective to one of the first and second conductivity cells.

Treatment fluid devices methods and systems

A treatment system for performing a treatment on a patient may include a treatment fluid preparation device having a pump connected by a fluid channel to a reservoir of a source fluid, the pump conveying the source fluid from the reservoir, through a filter, and combining the source fluid with a concentrate by pumping the source fluid with the concentrate to form a treatment fluid in a batch container. The treatment fluid preparation device may have a controller that controls a heater, the pump, and a memory. The controller starts the heater to warm the treatment fluid in the batch container at a time that is responsive to the treatment time stored in the memory. The controller also detects a pressure property of the filter to determine its integrity and outputs an indication of a failed batch if the pressure property indicates the integrity of the filter is insufficient.

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Boston, MA, United States of America

Goetz Friederichs